The authors explore the power and flexibility of using an operations research methodology known as linear programming to support health human resources (HHR) planning. The model takes as input estimates of the future need for healthcare providers and, in contrast to simulation, compares all feasible strategies to identify a long-term plan for achieving a balance between supply and demand at the...

The atherosclerotic intimal lesion contains endothelial cells, smooth muscle cells, monocytes/macrophages and T lymphocytes, which constitute a histamine-cytokine network that participates in chronic inflammatory responses. Monocytes/macrophages and T lymphocytes express the histamine-producing enzyme histidine decarboxylase (HDC), and specific histamine receptors (HHR), which are switched from...

Since the late 1990s, health human resource (HHR) policy in Canadian health care has been a mixture of consensus and conflict. Consensus appears to have emerged about the broad policy goals for Canadian HHR planning: immediate recruitment and retention goals, and long-term goals of greater cost-effectiveness and productivity from the health care workforce. This consensus has heightened in the w...

A series of tetrahydrofuran based compounds with a bicyclic core that provides conformational restriction were synthesized and investigated by radioligand displacement studies and functional [(35)S]GTPγS binding assays at the human histamine receptor (hHR) subtypes. The amines and ((1S,3R,5S,6R)- and ((1S,3S,5S,6R)-3-(1H-imidazol-5-yl)-2-oxabicyclo[3.1.0]hexan-6-yl)methanamine), exhibited submi...

Deep sequencing of viral or bacterial nucleic acids monitors the presence and diversity of microbes in select populations and locations. Metagenomic study of mammalian viromes can help trace paths of viral transmissions within or between species. High throughput sequencing of patient and untreated sewage microbiomes showed many sequences with no similarity to genomic sequences of known function...

AIMS Clinical data indicating a heart rate (HR) target during rate control therapy for permanent atrial fibrillation (AF) and assessing its eventual relationship with reduced exercise tolerance are lacking. The present study aims at investigating the impact of resting HR on the hemodynamic response to exercise in permanent AF patients by means of a computational cardiovascular model. METHODS ...

Abstract Potentially toxic element (PTE) pollution in farmland soil is a global problem. It vital to clarify the contributions of PTE from different sources potential ecological risk (PER) and human health risks (HHR), but existing research methods were incomplete. This study explored comprehensive scheme that combined source contribution assessment quantitatively assess PER, HHR priority sourc...

This paper gives the history and background of one of the oldest problems in algebraic topology, along with an outline of our solution to it. A rigorous account can be found in our preprint [HHR]. The third author has a website with numerous links to related papers and talks we have given on the subject since announcing our result in April, 2009.

INTRODUCTION The Hellenic Heart Registry on Percutaneous Coronary Interventions (HHR-PCI) was a prospective, observational registry of patients with stable angina or acute coronary syndromes who underwent percutaneous coronary intervention (PCI) between January 2008 and October 2010. METHODS HHR-PCI was a database that used a secure web-based interface for data entry by individual users. All ...

BACKGROUND The cynomolgus monkey (Macaca fascicularis) has been increasingly used as a non-human primate model in biomedical research. As establishing baseline thoracic radiography for the cynomolgus monkey is essential, we tested the hypothesis that age and sex may affect the thoracic radiography parameters of this species. METHODS Here, 697 healthy cynomolgus monkeys were segregated by sex ...