One of the greatest challenges in biomedical research, drug discovery and diagnostics is understanding how seemingly identical cells can respond differently to perturbagens including drugs for disease treatment. Although heterogeneity has become an accepted characteristic of a population of cells, in drug discovery it is not routinely evaluated or reported. The standard practice for cell-based,...

OBJECTIVES Single-photon emission computed tomography (SPECT) with iodine-123 (123I)-labeled N-isopropyl-p-iodoamphetamine (IMP) is widely used in measuring the cerebral blood flow (CBF) response to acetazolamide stress for assessment of cerebral vascular reserve. To quantitate CBF by means of SPECT with IMP, an autoradiographic (ARG) method has been developed and is widely used. Because the re...

[This corrects the article DOI: 10.1371/journal.pcbi.1005779.].

Copyright: 2014 The PLOS ONE Staff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Figure 4. Unthresholded t-maps of hand signal for ‘‘reward’’ vs. hand signal for ‘‘no reward.’’ The slice containing the vent...

This paper considers a measure of variable importance frequently used in variable selection methods based on decision trees and tree-based ensemble models, like CART, Random Forests and Gradient Boosting Machine. It is defined as the total heterogeneity reduction produced by a given covariate on the response variable when the sample space is recursively partitioned. Some authors showed that thi...