Herein we report a highly efficient method for nickel-catalyzed C-N bond formation between sulfonamides and aryl electrophiles. This technology provides generic access to a broad range of N-aryl and N-heteroaryl sulfonamide motifs, which are widely represented in drug discovery. Initial mechanistic studies suggest an energy-transfer mechanism wherein C-N bond reductive elimination occurs from a...

Sulfonylated aromatics are commonplace motifs in drugs and agrochemicals. However, methods for the direct synthesis of sulfonylated non-classical arene bioisosteres, which could improve physicochemical properties drug agrochemical candidates, limited. Here we report a solution to this challenge: one-pot halosulfonylation [1.1.1]propellane, [3.1.1]propellane bicyclo[1.1.0]butanes that proceeds u...

The Cover Feature shows the formation of two face-directed truncated tetrahedral enantiopure organic cages by employing dynamic imine condensation reactions a hexa-aldehyde precursor with trans-oriented diamines separately. In view its intrinsic porosity combined presence multiple vicinal di-imine corners and stable aromatic backbones, one was used as template for nucleation ultrafine Pd-nanopa...

Ni-deposited mesoporous graphitic carbon nitride (Ni-mpg-CNx) is introduced as an inexpensive, robust, easily synthesizable and recyclable material that functions integrated dual photocatalytic system. This overcomes the need of expensive photosensitizers, organic ligands additives well limitations catalyst deactivation in existing photo/Ni catalytic cross-coupling reactions. The Ni-mpg-CNx dem...

Palladium nanoparticles were deposited and reduced by gelatin as a safe edible, naturally occurring and cheap support. No extra reducing agents were used for the generation of Pd(0) nanoparticles from the Pd(II) salt. The nanoparticles of Pd supported on gelatin were characterized by SEM, TEM and AFM images, UV-Vis and XRD spectra and the amount of palladium entrapped in the gelatin was measure...