In this study we aimed to determine the incidence of herpes simplex virus (HSV) in the lungs of burns patients, and its association with the presence of adult respiratory distress syndrome (ARDS) and pneumonia. Haematoxylin and eosin (H&E), and immunohistochemical (IHC) staining for HSV was performed on lung tissue from 54 patients who had died following burn injury and from nine control cases....

Herpes simplex encephalitis is a severe neurological disease with high mortality and morbidity rates. Reactivated herpes simplex virus type 1 (HSV-1) can cause relapses and might even spread to the retina, where it can induce a potentially blinding eye disease, known as acute retinal necrosis. In the present study, the HSV-1 strains in the brain and eye of 2 patients with acute retinal necrosis...

Introduction: Herpes Simplex Virus type 1 (HSV-1) is the virus that most often infects oral cavity. HSV-1 in latent phase migrates to trigeminal ganglion after primary infection and can reactivate cause recurrent intraoral herpes (RIH). The recurrence of RIH multifactorial triggered by decreased immunity, fatigue, hypersensitivity, stress, ultraviolet. Case: Three male patients came Oral Diseas...

A polymerase chain reaction (PCR) was used to detect herpes simplex virus (HSV) deoxyribonucleic acid (DNA) in CSF of 109 patients with possible herpes simplex encephalitis. HSV DNA was found in 20/109 patients. In 14 of these patients the diagnosis was confirmed by a rise in CSF antibodies, isolation of HSV from the brain, or both. In 3 patients CSF antibodies did not rise and 3 patients did n...

objective: evaluation of bax encoding plasmid for increasing efficacy of dna vaccine plasmid encoding gb of herpes simplex virus type 1. materials and methods: we compared three different dosages of bax encoding plasmid (pcbax) including 10, 25 and 50 μg of plasmid dna. they were co-injected ineradermally with glycoprotein b (gb) of herpes simplex virus (hsv)-1 encoded plasmid (pcgb) in c57bl/6...

herpes simplex virus type 1 (hsv-1) is a member of the herpesviridae family that causes herpetic disease in human. during the last 25-30 years, many investigations have been conducted on pathogenesis and molecular biology of this virus in several countries. in iran hsv-1 has been isolated from patients and detected using immunological techniques. in this study, we investigated the molecular asp...

background: during the recent years, significant progress has been achieved on development of novel anti-viral drugs. natural products are assumed as the potential sources of novel anti-viral drugs; therefore, there are some previous studies reporting the anti-viral compounds from venomous animals. based on the significant value for tracing of non-toxic anti-viral agents from natural resources,...

Herpetic gingivostomatitis represents the most commonly observed clinical manifestation of primary herpes simplex virus (HSV) infection. HSV-1 has been associated with oro-labial disease, with most infections occurring during childhood, and HSV-2 with genital disease. However, it is possible for HSV-2 to cause oro-labial herpes and HSV-1 to cause genital herpes. An unusual case of acute herpeti...