نتایج جستجو برای: hepcidin

تعداد نتایج: 2675  

2016
Jing Liu Bingbing Sun Huijun Yin Sijin Liu

Iron is required for most forms of organisms, and it is the most essential element for the functions of many iron-containing proteins involved in oxygen transport, cellular respiration, DNA replication, and so on. Disorders of iron metabolism are associated with diverse diseases, including anemias (e.g., iron-deficiency anemia and anemia of chronic diseases) and iron overload diseases, such as ...

Journal: :Clinical chemistry 2012
Jason S Troutt Mats Rudling Lena Persson Lars Ståhle Bo Angelin Anthony M Butterfield Andrew E Schade Guoqing Cao Robert J Konrad

BACKGROUND Hepcidin-25 reduces iron absorption by binding to the intestinal iron transporter ferroportin and causing its degradation. Currently, little is known about the basal regulation of circulating hepcidin-25. In addition, although erythropoietin administration has been reported to decrease the circulating hepcidin concentration, information is limited regarding how other stimulators of e...

Journal: :Acta biochimica et biophysica Sinica 2013
Liqiong Wang Feng Gao Fang Yang Zhimin Wei Chenggang Zou

Hepcidin is a key regulator of iron metabolism. The expression of hepcidin is significantly induced by iron overload, inflammation, and infection of pathogens. Recent studies have indicated that the expression of hepcidin in the liver is also regulated during liver regeneration. However, the mechanism of the regulation of hepcidin expression and its role in liver regeneration remain unclear. In...

Journal: :Blood 2005
Lénaïck Détivaud Elizabeta Nemeth Karim Boudjema Bruno Turlin Marie-Bérengère Troadec Patricia Leroyer Martine Ropert Sylvie Jacquelinet Brice Courselaud Tomas Ganz Pierre Brissot Olivier Loréal

Hepcidin, a key regulator of iron metabolism, is synthesized by the liver. Hepcidin binds to the iron exporter ferroportin to regulate the release of iron into plasma from macrophages, hepatocytes, and enterocytes. We analyzed liver samples from patients undergoing hepatic surgery for cancer or receiving liver transplants and analyzed correlations between clinical parameters and liver hepcidin ...

Journal: :Haematologica 2012
Climent Casals-Pascual Honglei Huang Samira Lakhal-Littleton Marie L Thezenas Oscar Kai Charles R J C Newton David J Roberts

Hepcidin levels are high and iron absorption is limited in acute malaria. The mechanism(s) that regulate hepcidin secretion remain undefined. We have measured hepcidin concentration and cytokines in 100 Kenyan children with acute falciparum malaria and different degrees of anemia. Hepcidin was increased on admission and fell significantly one week and one month after treatment. The association ...

Journal: :Blood 2006
Carole Peyssonnaux Annelies S Zinkernagel Vivekanand Datta Xavier Lauth Randall S Johnson Victor Nizet

Hepcidin is an antimicrobial peptide secreted by the liver during inflammation that plays a central role in mammalian iron homeostasis. Here we demonstrate the endogenous expression of hepcidin by macrophages and neutrophils in vitro and in vivo. These myeloid cell types produced hepcidin in response to bacterial pathogens in a toll-like receptor 4 (TLR4)-dependent fashion. Conversely, bacteria...

2016
Yuxia Liu Ruiqing Zhang Liqin Zhu

Anemia is a frequent complication in the maintenance hemodialysis (MHD) patients. However, data on serum hepcidin level as a guide in MHD patients are limited. We aimed to investigate the clinical significance of serum hepcidin level on erythropoiesis-stimulating agents (ESAs) and/or intravenous iron therapy among MHD patients. A total of 32 MHD patients receiving ESAs and iron therapy were enr...

2013
Tanja Jaeggi Diego Moretti Jane Kvalsvig Penny A. Holding Harold Tjalsma Guus A. M. Kortman Irma Joosten Alice Mwangi Michael B. Zimmermann

Hepcidin regulation by competing stimuli such as infection and iron deficiency has not been studied in infants and it's yet unknown whether hepcidin regulatory pathways are fully functional in infants. In this cross-sectional study including 339 Kenyan infants aged 6.0±1.1 months (mean±SD), we assessed serum hepcidin-25, biomarkers of iron status and inflammation, and fecal calprotectin. Preval...

2008
Tomas Ganz Gordana Olbina Domenico Girelli Elizabeta Nemeth Mark Westerman

We developed and validated the first serum enzyme-linked immunosorbent assay for hepcidin, the principal iron-regulatory hormone that has been very difficult to measure. In healthy volunteers, the 5% to 95% range of hepcidin concentrations was 29 to 254 ng/mL in men (n 65) and 17 to 286 ng/mL in women (n 49), with median concentrations 112 versus 65 (P < .001). The lower limit of detection was ...

Journal: :The Biochemical journal 2011
Marie-Laure Island Nadia Fatih Patricia Leroyer Pierre Brissot Olivier Loreal

Hepcidin, a hormone mainly synthesized by hepatocytes and secreted in plasma, controls iron bioavailability. Thus, by inducing the internalization of the iron exporter ferroportin, it regulates iron release from macrophages, enterocytes and hepatocytes towards plasma. Abnormal levels of hepcidin expression alter plasma iron parameters and lead to iron metabolism disorders. Understanding the mec...

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