Studies in this laboratory for the past several years have been focused on the epidemiology of hemolytic streptococcal disease in New Haven. Attention is being given to the incidence and possible clinical and epidemiological significance of the various serological types of hemolytic streptococci recovered from residents of this city. Current experience indicates that in a city of some 160,000 i...

A method is described for the preparation from hemolytic streptococci of extracts containing a soluble precipitating substance. By the use of such extracts, it is shown that nearly all members of this family yield a common precipitable substance. So far, therefore, as concerns the precipitin reaction, the hemolytic streptococci form a practically homogeneous group.

These studies indicate that a single strain of hemolytic streptococci almost exclusively predominates the bacterial flora in patients with streptococcal infections and in the carrier state. One can proceed with confidence that, in isolating streptococci from throat swabs cultured on blood-agar plates, only a single hemolytic colony need be picked for serological grouping and typing.

I t has often been noted that on a blood agar plate seeded with influenzal sputum the colonies of Bacillus influenz6e are most numerous and grow to larger size in the neighborhood of colonies of certain other organisms, notably the staphylococcus. This phenomenon led the authors to conduct various experiments which may be summarized as follows: Blood agar plates were seeded uniformly with a pur...

The Phoenix system (Becton Dickinson Diagnostic Systems, Sparks, MD) was evaluated for identification (ID) to the species level of streptococci and enterococci. Two hundred clinical isolates were investigated: beta-hemolytic streptococci (n = 50), Streptococcus pneumoniae organisms (n = 46), viridans group streptococci (n = 31), Enterococcus faecium (n = 36), Enterococcus faecalis (n = 25), and...

Wide-zone, alpha-hemolytic streptococci are potential sources of false-positive throat cultures since they can be misinterpreted as beta-hemolytic streptococci. However, quantitative information regarding their occurrence in sick children was not available. Throat swabs from 312 children with pharyngitis were processed conventionally and also with pour-plate methods and examination of the posit...

Edicine is a therapeutic agent in the management of thromboembolic blockade. Streptokinase presently utilized clinical mase and an extracellular protein secreted by certain strains beta-hemolytic streptococci. It activates plasminogen to produce plasmin, enzyme that breaks down fibrin clots through specific lysine binding sites.

OBJECTIVES To investigate antibiotic sensitivities of Streptococcus pneumoniae, viridans streptococci, and group A hemolytic streptococci isolated from the culture materials obtained from the sinuses of patients undergoing functional endoscopic sinus surgery due to chronic sinusitis. PATIENTS AND METHODS We recruited 93 patients (63 males, 30 females; mean age 36+/-17.5; range 19 to 68 years)...

Many workers have shown that certain strains of supposed penicillin-sensitive bacteria may be resistant to penicillin. Since a clinical study of the effect of penicillin in infected root canals was contemplated it was thought desirable to ascertain the sensitivity of individual strains of streptococci, which are the organisms commonly isolated from infected root canals. At the same time it was ...

A test is described that could replace bacitracin susceptibility for presumptive identification of group A streptococci as well as 6.5% NaCl agar tolerance for presumptive identification of enterococcal streptococci. The L-pyrrolidonyl-beta-naphthylamide test, based on hydrolysis of pyrrolidonyl-beta-naphthylamide, was used in conjunction with the CAMP and bile-esculin tests to presumptively id...