UNLABELLED Docosahexaenoic acid (DHA) is an ω-3 polyunsaturated fatty acid that is essential in brain development and has structural and signaling roles. Acute DHA administration is neuroprotective and promotes functional recovery in animal models of adult spinal cord injury (SCI). However, the mechanisms underlying this recovery have not been fully characterized. Here we investigated the effec...

background: bone marrow stromal cells (bmsc) have been successfully employed for movement deficit recovery in spinal cord injury (sci) rat models. one of the unsettled problems in cell transplantation is the relative high proportion of cell death, specifically after neural differentiation. according to our previous studies, p75 receptor, known as the death receptor, is only expressed in bmsc in...

Spinal cord injury is the main cause of paraplegia, but effective therapies for it are lacking. Embryonic spinal cord transplantation is able to repair spinal cord injury, albeit with a large amount of neuronal apoptosis remaining in the spinal cord. MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist, is able to reduce cell death by decreasing the concentration of excitatory amino acids...

background in recent decades, the incidence of spinal cord injuries has increased. in a systemic review on epidemiology of traumatic spinal cord injury in developing countries reported 25.5/million cases per year. objectives to assess the quality of life (qol) of the veterans among iran-iraq war with chronic spinal cord injuries (sci) and to evaluate long-term impressions of sci on their qualit...

spinal cord injury (sci) actuate to complex cellular and molecular interactions within the central nervous system in a heave to repair the initial tissue damage. the pathophysiology of acute spinal cord injury (sci) involves primary and secondary mechanisms. neuroinflammation is an important secondary injury process in sci. the local inflammatory microenvironment within the injured spinal cord ...

We have previously reported that administration of a CD11d monoclonal antibody (mAb) improves recovery in a clip-compression model of SCI. In this model the CD11d mAb reduces the infiltration of activated leukocytes into the injured spinal cord (as indicated by reduced intraspinal MPO). However not all anti-inflammatory strategies have reported beneficial results, suggesting that success of the...

obesity is one of the most prevalent diet-related problems and increases the risk for diabetes mellitus, hypertension, atherosclerosis and dyslipidemia. cardio vascular disease is a major cause of morbidity and mortality in spinal cord injury (sci) patients. increased fat mass has also been identified as an important risk factor in chronic sci and weight management is recommended as a key cardi...

conclusions these results showed that the administration of sdf-1a increases the number of proliferating cells in the injured area in the spinal cord and improves functional recovery. results significant improvements in locomotor function were detected in the sdf-1 group compared with the sci and vehicle groups (p < 0.05). the results showed that sdf-1 treatment increased proliferative cells at...

objective: spinal cord injury (sci) causes inflammation, deformity and cell loss. it has been shown that melissa officinalis (mo), as herbal medicine, and dexamethasone (dex) are useful in the prevention of various neurological diseases. the present study evaluated combinational effects of dex and mo on spinal cord injury. materials and methods: thirty six adult male wistar rats were used in th...

in worldwide, an estimated 40 cases per 1 million people reported with new spinal cord injuries each year. people with spinal cord injuries suffer from severe physical, psychological, social and economic problems. damaged or lost cells can&apos;t be replaced when the spinal cord is injured; therefore, its function becomes disturbed permanently. despite the significant advances in the understand...