نتایج جستجو برای: hematopoietic system

تعداد نتایج: 2279844  

Nikougoftar Zarif M,

Cord blood hematopoietic stem cells are widely used as an alternative source for hematopoietic stem cells transplant. Increasing rate of patients who need hematopoietic stem cells transplant and many advantages of cord blood in comparison to bone marrow hematopoietic stem cells, have promoted banking of cord blood units. Cord blood banking requires accurate steps in donor selection, cord blood ...

آتشی, امیر, ابراهیمی, لیلا, احمد بیگی, ناصر, امید خدا, آزاده, ذنوبی, زهرا, سلیمانی, مسعود, نیکو گفتار, مهین, کاویانی, سعید,

Background and Objective: Nowadays, although umbilical cord blood is a commonly used source of hematopoietic stem cell, its low frequency of these cells is the main factor limiting its clinical application. The transplantation of hematopoietic stem cells derived from placenta tissue along with umbilical cord blood cells of the same sample may be an appropriate approach to solve this problem. In...

Journal: :The Journal of clinical investigation 2017
Vivian Y Chang Christina M Termini John P Chute

The hematopoietic system declines with age, resulting in decreased hematopoietic stem cell (HSC) self-renewal capacity, myeloid skewing, and immune cell depletion. Aging of the hematopoietic system is associated with an increased incidence of myeloid malignancies and a decline in adaptive immunity. Therefore, strategies to rejuvenate the hematopoietic system have important clinical implications...

Journal: :Blood 1999
I Hamaguchi X L Huang N Takakura J Tada Y Yamaguchi H Kodama T Suda

Recent studies have shown that long-term repopulating hematopoietic stem cells (HSCs) first appear in the aorta-gonad-mesonephros (AGM) region. Our immunohistochemistry study showed that TEK+ cells existed in the AGM region. Approximately 5% of AGM cells were TEK+, and most of these were CD34(+) and c-Kit+. We then established a coculture system of AGM cells using a stromal cell line, OP9, whic...

2010
Cristina Ferreras Christophe Lancrin Michael Lie-A-Ling Valerie Kouskoff Georges Lacaud

Although the critical requirement for the transcription factor RUNX1/AML1 at the onset of hematopoietic development is well established, little is known about its transcriptional targets at this pivotal stage of blood development. Using microarrays, we identified the uncharacterized gene AI467606 as a gene whose expression level is dramatically reduced in the absence of RUNX1. We further demons...

2011
Akira Niwa Toshio Heike Katsutsugu Umeda Koichi Oshima Itaru Kato Hiromi Sakai Hirofumi Suemori Tatsutoshi Nakahata Megumu K. Saito

Elucidating the in vitro differentiation of human embryonic stem (ES) and induced pluripotent stem (iPS) cells is important for understanding both normal and pathological hematopoietic development in vivo. For this purpose, a robust and simple hematopoietic differentiation system that can faithfully trace in vivo hematopoiesis is necessary. In this study, we established a novel serum-free monol...

Journal: :Blood 2011
Cristina Ferreras Christophe Lancrin Michael Lie-A-Ling Valerie Kouskoff Georges Lacaud

Although the critical requirement for the transcription factor RUNX1/AML1 at the onset of hematopoietic development is well established, little is known about its transcriptional targets at this pivotal stage of blood development. Using microarrays, we identified the uncharacterized gene AI467606 as a gene whose expression level is dramatically reduced in the absence of RUNX1. We further demons...

2016
Yulin Xu Wei Shan Xia Li Binsheng Wang Senquan Liu Yebo Wang Yan Long Ruxiu Tie Limengmeng Wang Shuyang Cai Hao Zhang Yu Lin Mingming Zhang Weiyan Zheng Yi Luo Xiaohong Yu Jiing-Kuan Yee Junfeng Ji He Huang

BACKGROUND The efficient generation of hematopoietic stem cells (HSCs) from human-induced pluripotent stem cells (iPSCs) holds great promise in personalized transplantation therapies. However, the derivation of functional and transplantable HSCs from iPSCs has had very limited success thus far. METHODS We developed a synthetic 3D hematopoietic niche system comprising nanofibers seeded with bo...

Journal: :Haematologica 2005
Marian Peeters Kam-Wing Ling Aneta Oziemlak Catherine Robin Elaine Dzierzak

BACKGROUND AND OBJECTIVES The first hematopoietic stem cells (HSC) in the mouse able to give rise to the adult hematopoietic system emerge at embryonic day (E) 10.5 in the intraembryonic aorta-gonads-mesonephros (AGM) region, as demonstrated by transplantation into irradiated adult recipients. It has been shown by transplantation into conditioned neonatal or hematopoietic mutant adult recipient...

Journal: :Journal of Nihon University Medical Association 2015

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