A number of mutant hemoglobins are inordinately unstable, denaturing in circulating red cells into Heinz bodies, resulting in congenital Heinz body hemolytic anemia (CHBHA). We have emphasized that most such hemoglobins involve amino acid substitutions at sites neighboring the heme group of the beta-polypeptide chain, and have shown that heme binding to globin is diminished thereby. Thus, hemes...

The authors shall discuss Heinz inequalities involving Riemann-Liouville fractional integrals for certain unitarily invariant norms. By using the convexity of function and fractional Hermit-Hadamard integral inequality, some refinements of Heinz inequalities are derived.

In red cells from patients with sickle cell anemia, hemoglobin S denatures and forms Heinz bodies. Binding of Heinz bodies to the inner surface of the sickle cell membrane promotes clustering and colocalization of the membrane protein band 3, outer surface-bound autologous IgG and, to some extent, the membrane proteins glycophorin and ankyrin. Loss of transbilayer lipid asymmetry is also found ...

U-M Peace Corps representative [email protected] [1] Our U-M Peace Corps office is staffed by one or more Peace Corps recruiters who are returned Peace Corps Volunteers and U-M graduate students. Our Peace Corps recruiters provide information about the Peace Corps, advise those who may consider joining, and accept applications from prospective volunteers. The Peace Corps recruiters maintain...

U-M Peace Corps representative [email protected] [1] Our U-M Peace Corps office is staffed by one or more Peace Corps recruiters who are returned Peace Corps Volunteers and U-M graduate students. Our Peace Corps recruiters provide information about the Peace Corps, advise those who may consider joining, and accept applications from prospective volunteers. The Peace Corps recruiters maintain...

U-M Peace Corps representative [email protected] [1] Our U-M Peace Corps office is staffed by one or more Peace Corps recruiters who are returned Peace Corps Volunteers and U-M graduate students. Our Peace Corps recruiters provide information about the Peace Corps, advise those who may consider joining, and accept applications from prospective volunteers. The Peace Corps recruiters maintain...

Mental files theory explains why children pass many perspective taking tasks like the false belief test around age 4 (Perner & Leahy, 2016). It also explains why older children struggle to understand that beliefs about an object depend on how one is acquainted with it (intensionality or aspectuality). If Heinz looks at an object that is both a die and an eraser, but cannot tell by looking that ...

The ultimate cause of destruction of red blood cells (RBCs) after oxidative damage with Heinz body formation is not well understood. We correlated the changes in RBC morphology and membrane protein composition after oxidant treatment with the alterations in deformability of whole cells and cell membranes. The incubation of RBCs with phenylhydrazine concentrations of 0.3 to 100 mg/dL at 37 degre...

In earlier model studies we demonstrated that artificially denatured hemoglobin binds to and clusters the protein, band 3, in the plane of the erythrocyte membrane. To determine whether denatured hemoglobin also clusters band 3 in vivo, we have compared the locations of denatured hemoglobin aggregates (Heinz bodies) with band 3 in sickle cells using phase contrast and immunofluorescence microsc...