نتایج جستجو برای: heat shock protein 27 hsp27 inhibitors

تعداد نتایج: 1741445  

Journal: :European journal of endocrinology 2003
H Tokuda M Niwa H Ito Y Oiso K Kato O Kozawa

OBJECTIVE We have reported that endothelin-1 (ET-1) activates p38 mitogen-activated protein (MAP) kinase through protein kinase C in osteoblast-like MC3T3-E1 cells, and that p38 MAP kinase plays a role in the ET-1-induced heat shock protein 27 (HSP27). Recently, we found that stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) is activated by ET-1 in these cells. In the present s...

2006
Elaine H. Richards Eileen Hickey Lee Weber John R. W. Masters

In contrast to most metastatic cancers, testicular germ cell tumors are cured in more than 80% of patients using cisplatin-based combination chemotherapy. Testis tumor cells in vitro retain their sensitivity to diemotherapeutic drugs, radiation, and other stresses, such as heat shock. Having shown that this is associated with low constitutive levels of heat shock protein (HSP) 27, we determined...

2013
Lingbo Cai Xiang Ma Shan Liu Jinjuan Liu Wei Wang Yugui Cui Wei Ding Yundong Mao Huiping Chen Jie Huang Zuomin Zhou Jiayin Liu

Heat shock protein 27 (Hsp27) is a heat shock protein family member which can inhibit apoptosis. Our previous studies reported down-regulated Hsp27 in ovarian tissue derived from women with polycystic ovary syndrome (PCOS) however, the exact effect of Hsp27 on oocyte maturation and developmental competence in PCOS is unclear. The effect of Hsp27 over-expression was studied in vitro using oocyte...

Journal: :Molecular pharmacology 2014
Fadi Maged Shokry Gurgis William Ziaziaris Lenka Munoz

Mitogen-activated protein kinase (MAPK)-activated protein kinase 2 (MAPKAPK-2 or MK2) is a downstream substrate of the p38 MAPK responsible for the signaling events influencing inflammation, cell division and differentiation, apoptosis, and cell motility in response to a wide range of extracellular stimuli. After the failure of p38 MAPK inhibitors in clinical trials, MK2 was unveiled as a poten...

Journal: :International journal of oncology 2010
Sung-Chul Lim Hong-Quan Duong Jeong Eun Choi Keshab Raj Parajuli Ho Sung Kang Song Iy Han

Previously, we showed that mild heat shock modulates patterns of cell death in response to glucose deprivation (GD), a common characteristic of the tumor microenvironment, by switching necrosis to apoptosis through ERK-dependent suppression of reactive oxygen species production in A549 cells. In the present study, we further examined the molecular mechanism underlying mild heat shock-induced ne...

Journal: :Clinica chimica acta; international journal of clinical chemistry 2012
Majid Ghayour-Mobarhan Hamidreza Saber Gordon A A Ferns

Heat shock proteins (Hsps) comprise several families of proteins expressed by a number of cell types following exposure to stressful environmental conditions that include heat, free radicals, toxins and ischemia, and are particularly involved in the recognition and renaturation of mis-folded proteins. Heat shock protein-27 (Hsp27) is a member of the small Hsp (sHsp) family with a molecular weig...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2007
Yong Zhang Xun Shen

PURPOSE Heat shock protein 27 (Hsp27) is up-regulated in multiple malignancies and implicated in cisplatin resistance. It is attempted to know how Hsp27 endues cell with cisplatin resistance by interfering with upstream of both apoptosis signal-regulating kinase 1 (ASK1)/p38 mitogen-activated protein kinase-activated apoptotic signaling and serine/threonine kinase Akt-dependent survival signali...

Journal: :American journal of physiology. Renal physiology 2008
Aparna Vidyasagar Shannon Reese Zeki Acun Debra Hullett Arjang Djamali

We hypothesized that heat shock protein 27 (HSP27), a small heat shock protein with actin-remodeling properties, is involved in the pathogenesis of kidney tubulointerstitial fibrosis. We first examined its expression in the rat unilateral ureteral obstruction (UUO) model of kidney fibrosis and epithelial-to-mesenchymal transition (EMT). Immunoblot analyses showed that UUO resulted in significan...

Journal: :Circulation 2006
Haing Kee Park Eui-Chul Park Sung Won Bae Mi Young Park Seon Woon Kim Hwan Soo Yoo Munkhtsetseg Tudev Young Hye Ko Yoon-Ho Choi Sungjoo Kim Dong-Ik Kim Young Wook Kim Byung Boong Lee Jong-Bok Yoon Jeong Euy Park

BACKGROUND We intended to identify proteins that are differentially expressed in human atherosclerotic plaques. METHODS AND RESULTS Comparative 2-dimensional electrophoretic analysis on carotid atherosclerotic endarterectomy specimens (n = 10) revealed that heat shock protein 27 (Hsp27) expression was significantly increased in the nearby normal-appearing area compared with the plaque core ar...

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