BACKGROUND Previous studies have shown that the TRPV1 ion channel plays a critical role in the development of heat hyperalgesia after inflammation, as inflamed TRPV1-/- mice develop mechanical allodynia but fail to develop thermal hyperalgesia. In order to further investigate the role of TRPV1, we have used an ex vivo skin/nerve/DRG preparation to examine the effects of CFA-induced-inflammation...

The object of the present paper is to study temperature distribution and thermal stresses of a functionally graded thick hollow cylinder with temperature dependent material properties. All the material properties except Poisson’s ratio are assumed to be dependent on temperature. The nonlinear heat conduction with temperature dependent thermal conductivity and specific heat capacity is reduced t...

During the course of a psychophysical study of fibromyalgia syndrome (FMS), one of the subjects with a long history of headache and facial pain displayed an extraordinarily severe thermal allodynia. Her stimulus-response function for ratings of cutaneous heat pain revealed a sensitivity clearly beyond that of normal controls and most FMS subjects. Specially designed psychophysical methods showe...

MSOffice1] Background: Many individuals diagnosed with Multiple Sclerosis (MS) are sensitive to increased body temperature, which has been recognized to correlate with the symptom of fatigue. The need to investigate this association has been highlighted. The aim of the study was to investigate the occurrence of heat sensitivity and its relations to disease course, disability, common MS-related ...

In the present study, the effective parameters of water-Al2O3 nanofluid flowing in flat tubes are investigated using the EFAST Sensitivity Analysis (SA) method. The SA is performed using GMDH type artificial neural networks (ANN) which are based on validated numerical data of two phase modeling of nanofluid flow in flat tubes. There are five design variables namely: tube flattening (H), flow ra...

in this study, a new method for joining aluminum tubes in subsurface structures using steel converting and aluminum welding are presented and reviewed. but near the weld area is under high thermal cycle and will cause residual stresses in heat affected zone. therefore for assessment of proposed connection from the perspective of residual stress by using the finite element method welding of tube...

metric (mapping evapotranspiration at high resolution with internalized calibration) is known as an appropriate surface energy balance model for the estimation of the spatial distribution of evapotranspiration (et) in semi-arid regions. based on lysimeter measurements, metric has shown et estimates of 10% on a sub-field scale on a daily basis. there is a need to identify how the model is sensit...

We present revised probability density functions (PDF) for climate system properties (climate sensitivity, rate of deep-ocean heat uptake, and the net aerosol forcing strength) that include the effect on 20th century temperature changes of natural as well as anthropogenic forcings. The additional natural forcings, primarily the cooling by volcanic eruptions, affect the PDF by requiring a higher...