The endoplasmic reticulum resident heat shock protein gp96 chaperons peptides, including those derived from tumor Ags, on their way to presentation by MHC class I. Replacement of the endoplasmic reticulum retention signal of gp96 with the Fc portion of murine IgG1 generated a secretory form of gp96, gp96-Ig. Tumor cells secreting gp96-Ig exhibited decreased tumorigenicity and increased immunoge...

BACKGROUND Heat shock protein 90 (HSP90), a molecular chaperone associated with the activation of client proteins, was recently reported to play an important role in immunologic reactions. To date, the role of HSP90 in solid organ transplantations has remained unknown. The aim of this study was to evaluate the relationship between serum HSP90α levels and acute allograft rejection after organ an...

BACKGROUND Rejection is the major obstacle to survival after cardiac transplantation. We investigated whether overexpression of heat shock protein (Hsp)-27 in mouse hearts protects against acute rejection and the mechanisms of such protection. METHODS Hearts from B10.A mice overexpressing human Hsp-27 (Hsp-27tg), or Hsp-27-negative hearts from littermate controls (LCs) were transplanted into ...

Experiments were conducted to evaluate the performance of a low heat rejection (LHR) diesel engine. Performance parameters and emission levels were determined at various magnitudes of brake mean effective pressure. Combustion characteristics of the engine were measured with TDC (top dead centre) encoder, pressure transducer, console and special pressure-crank angle software package at peak load...

Shell and Tube heat exchanger system (STHX) is widely used in food processing and chemical industries because it can sustain wide range of temperature and pressure. The main purpose is to exchange heat between hot and cool fluid. The designed controllers will regulate the temperature of outlet fluid to a desired set point in the shortest possible time irrespective of load and process disturbanc...