BACKGROUND There are few data on empiric, stepped therapy for heartburn relief or subsequent relapse in primary care. AIMS To compare heartburn relief produced by a proton pump inhibitor-start or an H(2)-receptor antagonist-start with step-up therapy, as needed, followed by a treatment-free period to assess relapse. METHODS Heartburn-dominant uninvestigated dyspepsia patients from 46 primar...

BACKGROUND Folklore can originate by detection of actual associations between seemingly unrelated events and perpetuated through oral tradition. The objective of this study was to determine whether a common pregnancy belief that women who experience a lot of heartburn give birth to newborns with a lot of hair is accurate. METHODS Sixty-four pregnant women ranked the severity of their degree o...

The definition of functional heartburn has been refined over the years. It is currently described, based upon Rome IV criteria, as typical heartburn symptoms in the presence of normal upper endoscopy findings (including normal biopsies), normal esophageal pH testing, and a negative association between symptoms and reflux events. Functional heartburn is very common, affecting women more than men...

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Despite major advances in our understanding of reflux disease, the management of this disorder still presents many challenges. Reduction of heartburn is the most readily apparent objective for the patient with reflux disease. Thus the ability to measure heartburn accurately is of fundamental importance to clinical research in reflux disease. Here, the available data on the assessment of reflux ...

aim : to determine the associated factors of reflux duration, using quantile regression model. background : reflux is one of the most prevalent gastrointestinal disorders.  statistical tools are widely used to assess the associated factors on reflux severity and frequency. patients and methods : a door to door questionnaire has been used to evaluate gastrointestinal symptoms including reflux an...