Abstract Background The management of acute decompensated heart failure (ADHF) often requires intensive care. However, the effects early care unit (ICU)/coronary (CCU) admission on activities daily living (ADL) in ADHF patients have not been precisely evaluated. Thus, we assessed whether ICU entry can improve post-discharge ADL performance these patients. Methods and results (New York Heart Ass...

BACKGROUND Ventricular tachycardia (VT) is an important cause of late morbidity and mortality in repaired congenital heart disease. The substrate often includes anatomic isthmuses that can be transected by radiofrequency catheter ablation similar to isthmus block for atrial flutter. This study evaluates the long-term efficacy of isthmus block for treatment of re-entry VT in adults with repaired...

What is your laboratory currently working on? We work on skeletal myogenesis and cardiogenesis. The skeletal myogenesis research involves studying gene regulatory networks that govern cell fate choices and the entry into the myogenic programme in the embryo, as well as satellite cell behaviour during muscle regeneration in the adult. For cardiogenesis, work involves examining the second heart f...

The heart derives most of its energy via mitochondrial oxidative metabolism. The heart’s fuels or energy substrates include fatty acids, lactate, glucose, and ketones. Substrate concentrations vary during the day, driven mainly by postprandial status. Entry into mitochondrial oxidation requires metabolism to acetyl-coenzyme A (CoA), the fuel of the tricarboxylic acid (TCA) cycle. Acetyl-CoA oxi...

We have examined observational data from four published studies investigating the incidence of postoperative silent myocardial ischaemia (post-SMI) for the effects of chronic intercurrent therapy with β-adrenoceptor blockade or chronic calcium channel entry blockade. A total of 453 patients underwent ambulatory ECG monitoring before and for 2 days after non-cardiac surgery; 79 patients were rec...

OBJECTIVES To compare the survival of patients thought to have heart failure in general practice (GP-HF) with that of patients with heart failure in hospital (hospital-HF), patients with heart disease but without heart failure (non-HF), and a control group without heart disease. DESIGN AND SETTING Cross sectional study from general practice with a prospective follow up from 5.3 to 7.4 years. ...

development of a numerical model which describes launching of offshore jackets from barge is presented in this paper. in this model, in addition to capabilities of commercial softwares, water entry forces on jacket members and an implicit newmark solution technique are included. the results are in general agreement with other numerical software’s available (sacs). fluid forces acting on jacket ...

AIMS Cardiomyocyte proliferation gradually declines during embryogenesis resulting in severely limited regenerative capacities in the adult heart. Understanding the developmental processes controlling cardiomyocyte proliferation may thus identify new therapeutic targets to modulate the cell-cycle activity of cardiomyocytes in the adult heart. This study aims to determine the mechanism by which ...

OBJECTIVE To determine which groups of patients may derive particular benefit or experience harm from the use of low dose aspirin for the primary prevention of coronary heart disease. DESIGN Randomised controlled trial. SETTING 108 group practices in the Medical Research Council's general practice research framework who were taking part in the thrombosis prevention trial. PARTICIPANTS 549...