Chemotherapy is an effective weapon in the battle against cancer, but numerous cancer patients are either not sensitive to chemotherapy or develop drug resistance to current chemotherapy regimens. Therefore, an effective chemotherapy mechanism that enhances tumor sensitivity to chemotherapeutics is urgently needed. The aim of the present study was to determine the antitumor activity of dihydrom...

Patients with Head and Neck Squamous Cell Carcinoma (HNSCC) often develop synchronous primary cancers. It is important to detect synchronous cancer in HNSCC patients, because it influences treatment selection of primary cancer. The aim of the study was to evaluate the diagnostic role and limitations of pre-treatment 2-deoxy-2(F-18) Fluoro-D-Glucose Positron Emission Tomography (FDG-PET) in pati...

Introduction: Squamous cell carcinoma (SCC) is the most common head and neck malignancy. Smoking, alcohol consumption, viral infections, exposure, oral hygiene, and dietary, genetic, and occupational factors are the most important etiologic factors. The aim of this study was determining the incidence of etiologic factors in head and neck SCC.  Materials and Methods: This is a cross-sectiona...

OBJECTIVE Stereotactic body radiotherapy (SBRT) is increasingly used to treat a variety of tumors, including head and neck squamous cell carcinoma (HNSCC) in the recurrent setting. While there are published data for re-irradiation using SBRT for HNSCC, there are limited data supporting its use as upfront treatment for locally advanced disease. STUDY DESIGN/METHODS Here, we describe three pati...

Head and neck squamous cell carcinoma (HNSCC) is the sixth leading malignancy worldwide, with a poor prognosis limited treatment options. Molecularly targeted therapies for HNSCC are still lacking. However, recent reports provide novel insights about many molecular alterations in that may be useful future therapies. Therefore, it necessary to identify new biomarkers better prediction of disease...

Tripartite motif-containing 24 (TRIM24), a member of the transcriptional intermediary factor 1 family, functions as a co-regulator that positively or negatively modulates the transcriptional activities of several nuclear receptors. The aim of this study was to investigate TRIM24 expression and its clinical significance in head and neck squamous cell carcinoma. The expression levels of TRIM24 va...

Background: p53 accumulation in head and neck squamous cell carcinoma (HNSCC) cells creates a targetable tumor antigen. Adjuvant dendritic cell (DC)–based vaccination against p53was tested in a phase I

introduction: the presence of her-2 has been shown to be a prognostic factor in many kinds of cancers, but its role in head and neck squamous cell carcinoma (hnscc) is not still defined. the purpose of the current study is to investigate the role of her-2 in hnscc and its correlation with various clinicopathologic parameters.   materials and methods: peripheral blood samples were obtained from ...

Metastatic cervical lymph nodes are a frequent finding in head and neck squamous cell carcinoma (HNSCC). If non-surgical approach is primarily chosen, therapy response evaluation of the primary tumor affected necessary follow-up. Supplementary contrast-enhanced ultrasound (CEUS) can be used to precisely visualize microcirculation target lesion neck, whereby malignant benign findings differ thei...