نتایج جستجو برای: hdl c وapoa i

تعداد نتایج: 1966907  

2013
David Nguyen Margaret Nickel Chiharu Mizuguchi Hiroyuki Saito Sissel Lund-Katz Michael C. Phillips

Although the partitioning of apolipoprotein A-I (apoA-I) molecules in plasma between high-density lipoprotein (HDL)-bound and -unbound states is an integral part of HDL metabolism, the factors that control binding of apoA-I to HDL particles are poorly understood. To address this gap in knowledge, we investigated how the properties of the apoA-I tertiary structure domains and surface characteris...

Journal: :Atherosclerosis 2016
Demidmaa Tuvdendorj Alejandro O Munoz Viviana Ruiz-Barros Jean-Marc Schwarz Giuseppe Montalto Manisha Chandalia Lawrence C Sowers Manfredi Rizzo Elizabeth J Murphy Nicola Abate

BACKGROUNDS AND AIMS Low concentrations of plasma HDL-C are associated with the development of atherosclerotic cardiovascular diseases and type 2 diabetes. Here we aimed to explore the relationship between the in vivo fractional synthesis of triglycerides (fTG) in subcutaneous (s.q.) abdominal adipose tissue (AT), HDL-C concentrations and HDL particle size composition in non-diabetic humans. ...

2014
Tingting Du Gang Yuan Muxun Zhang Xinrong Zhou Xingxing Sun Xuefeng Yu

BACKGROUND To directly compare traditional lipid ratios (total cholesterol [TC]/high density lipoprotein cholesterol [HDL-C], non-HDL-C/HDL-C, low density lipoprotein cholesterol [LDL-C]/HDL-C, and triglycerides [TG]/HDL-C), apolipoprotein B (apoB)/apolipoprotein A-I (apoA-I) ratio, visceral adiposity index (VAI), lipid accumulation product (LAP), and the product of TG and fasting glucose (TyG)...

2010
Margarita de la Llera-Moya Denise Drazul-Schrader Bela F. Asztalos Marina Cuchel Daniel J. Rader George H. Rothblat

Objective—We measured efflux from macrophages to apolipoprotein B-depleted serum from 263 specimens and found instances in which serum having similar high-density lipoprotein cholesterol (HDL-C) differed in their efflux capacity. Thus, we wanted to elucidate why efflux capacity could be independent of total HDL-C or apolipoprotein A-I (apoA-I). Methods and Results—To understand why sera with si...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2010
Margarita de la Llera-Moya Denise Drazul-Schrader Bela F Asztalos Marina Cuchel Daniel J Rader George H Rothblat

OBJECTIVE We measured efflux from macrophages to apolipoprotein B-depleted serum from 263 specimens and found instances in which serum having similar high-density lipoprotein cholesterol (HDL-C) differed in their efflux capacity. Thus, we wanted to elucidate why efflux capacity could be independent of total HDL-C or apolipoprotein A-I (apoA-I). METHODS AND RESULTS To understand why sera with ...

2005
Daniel J. Rader Ryan E. Moore Mohamad Navab John S. Millar Francesca Zimetti Susan Hama George H. Rothblat

To test the hypothesis that apolipoprotein A-I (apoA-I) functions specifically to inhibit atherosclerosis independent of the level of high-density lipoprotein cholesterol (HDL-C) by promoting both reverse cholesterol transport and HDL antiinflammatory function in vivo, we established a murine atherosclerosis model of apoA-I deficiency in which the level of HDL-C is well maintained. ApoA-I / mic...

Journal: :Circulation research 2005
Ryan E Moore Mohamad Navab John S Millar Francesca Zimetti Susan Hama George H Rothblat Daniel J Rader

To test the hypothesis that apolipoprotein A-I (apoA-I) functions specifically to inhibit atherosclerosis independent of the level of high-density lipoprotein cholesterol (HDL-C) by promoting both reverse cholesterol transport and HDL antiinflammatory function in vivo, we established a murine atherosclerosis model of apoA-I deficiency in which the level of HDL-C is well maintained. ApoA-I-/- mi...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2003
Marina Cuchel Daniel J Rader

Astrong inverse association exists between plasma HDL cholesterol (HDL-C) levels and incidence of coronary artery disease.1 Although environmental factors play a role, variation in HDL-C levels are at least 50% genetically determined.2 The genetics of syndromes of very low HDL-C have been extensively studied. Mutations in apoA-I (the major HDL structural protein), ABCA1 (which promotes efflux o...

Journal: :Journal of atherosclerosis and thrombosis 2010
Yuhei Shiga Shin-ichiro Miura Ryoko Mitsutake Akira Kawamura Yoshinari Uehara Keijiro Saku

AIM Since we previously reported that lower levels of HDL-C may be most useful for predicting coronary artery disease (CAD) as assessed by multi-detector row computed tomography (MDCT), we sought to confirm, among the levels of LDL-C, HDL-C, non-HDL-C (total cholesterol minus HDL-C) and the ratio of LDL-C to HDL-C (LDL-C/HDL-C), which is most closely related to the presence of CAD. METHODS AN...

2017
K Bora MS Pathak P Borah Md.I Hussain D Das

Cardiovascular disease (CVD) risk factors, and particularly decreased high density lipoprotein cholesterol (HDL-C) dyslipidemia are prevalent in Assam, India. This study was undertaken to investigate whether Apolipoprotein A-I (APOA1) gene polymorphisms (G-75A and C+83T) were associated with i) the risk for decreased HDL-C, and ii) other CVD risk factors, viz. serum lipids, atherogenic indices,...

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