S-Methylmethionine sulfonium (SMMS) was reported to have wound-healing effects; we therefore have investigated the photoprotective effect of SMMS in the present study. SMMS increased the viability of keratinocyte progenitor cells (KPCs) and human dermal fibroblasts (hDFs) following ultraviolet B (UVB) irradiation, and reduced the UVB-induced apoptosis in these cells. SMMS increased the phosphor...

Neprilysin (NPL) is a wrinkle-inducing membrane bound elastase that expressed abundantly in UV-exposed and aged dermal fibroblasts (JBC2010). The overexpression of NPL essentially associated with enhanced epithelial-mesenchymal cytokine interactions (EMCI) mainly via IL-1α which has distinct potential to stimulate the expression by human (HDFs)(BJ2012). over-expression also accelerates wrinkle ...

Hypoxia, a condition of reduced oxygen concentration, is observed in many physiological and pathophysiological states. However, there is rather limited information regarding hypoxic effects in the processes of immortalization and senescence of human cells. Here, the effects of hypoxia induced by either 1.5% O2, or by a hypoxia-mimetic agent, CoCl2, on the protein expression of normal human dipl...

BACKGROUND Mesenchymal stem cells within the stromal-vascular fraction of subcutaneous adipose tissue, adipose-derived stem cells (ADSCs), produced soluble factors and they exhibit diverse pharmacological effects in skin biology. OBJECTIVE The present study examines the protective effect of ADSCs for human dermal fibroblasts (HDFs) through anti-oxidation in a tert-butyl hydroperoxide (tbOOH) ...

BACKGROUND The interaction between ionizing radiation and substances in cells will induce the production of free radicals. These free radicals inflict damage to important biomolecules such as chromosomes, proteins and lipids which consequently trigger the expression of genes which are involved in protecting the cells or repair the oxidative damages. Honey has been known for its antioxidant prop...

We propose repair pipelining , a technique that speeds up the performance in general erasure-coded storage. By carefully scheduling of failed data small-size units across storage nodes pipelined manner, reduces single-block time to approximately same as normal read for single block homogeneous environments. further design different extensions algorithms heterogeneous environments and multi-bloc...

The IFN-inducible IFI16 and AIM2 proteins act as innate immune sensors for cytosolic double-stranded DNA (dsDNA). On sensing dsDNA, the IFI16 protein induces the expression of IFN-β whereas the AIM2 protein forms an inflammasome, which promotes the secretion of IL-1β. Given that the knockdown of IFI16 expression in human diploid fibroblasts (HDF) delays the onset of cellular senescence, we inve...

Background & Aims: Induced pluripotent stem cells (iPSCs) have the capability to undergo unlimited selfrenewal and differentiation into all cell types in the body. These cells are artificially derived from a nonpluripotent cell, typically human dermal fibroblasts (HDFs). The study of cytogenetic stability of these cells, in order to use iPS cells and apply studies in therapeutic applications, i...

Mosquito is a lightweight and adaptive physical design framework for Hadoop. Mosquito connects to existing data pipelines in Hadoop MapReduce and/or HDFS, observes the data, and creates better physical designs, i.e. indexes, as a byproduct. Our approach is minimally invasive, yet it allows users and developers to easily improve the runtime of Hadoop. We present three important use cases: first,...

The periodontal ligament (PDL) is one of the connective tissues located between the tooth and bone. It is characterized by rapid turnover. Periodontal ligament fibroblasts (PDLFs) play major roles in the rapid turnover of the PDL. Microarray analysis of human PDLFs (HPDLFs) and human dermal fibroblasts (HDFs) demonstrated markedly high expression of chemokine (CXC motif) ligand 12 (CXCL12) in t...