نتایج جستجو برای: hcv genome

تعداد نتایج: 249841  

Journal: :The Journal of clinical investigation 1993
K T Nouri Aria R Sallie D Sangar G J Alexander H Smith J Byrne B Portmann A L Eddleston R Williams

Nonisotopic in situ hybridization using a digoxigenin-labeled cDNA probe to the 3' nonstructural region (NS5) of hepatitis C virus (HCV) was performed on liver tissue from 33 patients. The results were compared with PCR detection of HCV RNA performed on 24 of the biopsies. Nonisotopic in situ hybridization correlated well with PCR findings. Hybridization signals were detected, within the cytopl...

Journal: :iranian journal of virology 0
a alborzi department of virology, faculty of medical sciences, tarbiat modares university, tehran, iran t bamdad department of virology, faculty of medical sciences, tarbiat modares university, tehran, iran m ghaderi department of virology, faculty of medical sciences, tarbiat modares university, tehran, iran h salimi center for virology, burnet institute, melbourne, vic, australia; department of infectious diseases, monash university, melbourne, vic, australia p davoodian infectious & tropical diseases research center, hormozgan university of medical sciences, bandar abbas, iran sh merat digestive diseases research center, shariati hospital, tehran university of medical sciences, tehran, iran

background and aims: hepatitis c virus (hcv) can cause hepatocellular carcinoma (hcc) in a significant proportion (≈ 20 %) of individuals with chronic hcv infection (chc). currently, chc is treated with peginterferon and ribavirin, which depending on genotype approximately 50 to 70% of patients are cured. the so-called “extrahepatic hcv infection” or viral replication in regions of the body oth...

Abbasali Raz Mahdi Forouzandeh Moghadam, Mahdi Paryan Samira Mohammadi Yeganeh Siamak Mirab Samiee Vahid Kia

  Background: Due to some limitations of serological methods in diagnosis of patients infected with HIV-1 (human immunodeficiency virus) and HCV (hepatitis C virus), it is profoundly important to use molecular methods for the detecting of these infectious agents. However, the most significant problems are the exorbitant cost of these methods and the need of a thermocycler which is an expensive...

Journal: :The Journal of general virology 2005
Patricia Baré Ivana Massud Cecilia Parodi Liliana Belmonte Gabriel García Marcelo Campos Nebel Marcelo Corti Miguel Tezanos Pinto Raúl Pérez Bianco María M Bracco Rodolfo Campos Beatriz Ruibal Ares

In order to investigate hepatitis C virus (HCV) persistence and replication in peripheral blood mononuclear cells (PBMC) from a group of haemophilic individuals, HCV production and release to PBMC culture supernatants (SNs) from HCV singly infected patients and HIV/HCV co-infected patients was studied. HCV RNA+ SNs were found more frequently from HIV/HCV co-infected individuals (89.5 %) with po...

Journal: :Journal of virology 2013
Qingxia Han David Manna Kerry Belton Richard Cole Kouacou V Konan

Hepatitis C Virus (HCV) NS4B protein has many roles in HCV genome replication. Recently, our laboratory (Q. Han, J. Aligo, D. Manna, K. Belton, S. V. Chintapalli, Y. Hong, R. L. Patterson, D. B. van Rossum, and K. V. Konan, J. Virol. 85:6464-6479, 2011) and others (D. M. Jones, A. H. Patel, P. Targett-Adams, and J. McLauchlan, J. Virol. 83:2163-2177, 2009; D. Paul, I. Romero-Brey, J. Gouttenoir...

Journal: :Kathmandu University medical journal 2003
Sarala Joshi

HCV is a positive strand RNA virus, and is a member of the Family Flaviviridie. HCV show substantial nucleotide sequence variability distributed throughout the viral genome, particularly the HVR1 region that is suggested to be immunogenic in humans. HVR1 is the most heterogeneous region within the E2 genome and peptide corresponding to this region, can be detected by homologous sera. To study t...

Journal: :The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy 2021

Background: Approximately 5-60% of hemodialysis patients have comorbid hepatitis C virus (HCV) infection. The survival rate HCV is lower than those without due to the risk liver fibrosis and cardiovascular disease. combination Elbasvir Grazoprevir drug choice for these with genotype 1 4 which mainly inherited in populations Indonesia. However, a high cost required this genome testing. Eradicati...

Journal: :Nucleic acids research 2004
Gaël Cristofari Roland Ivanyi-Nagy Caroline Gabus Steeve Boulant Jean-Pierre Lavergne François Penin Jean-Luc Darlix

The hepatitis C virus (HCV) is an important human pathogen causing chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. HCV is an enveloped virus with a positive-sense, single-stranded RNA genome encoding a single polyprotein that is processed to generate viral proteins. Several hundred molecules of the structural Core protein are thought to coat the genome in the viral particle, as...

Journal: :Journal of clinical microbiology 1993
B Wirz J D Tratschin H K Müller D B Mitchell

Reverse transcription coupled with the polymerase chain reaction (RT-PCR) was used for the detection and differentiation of pestiviruses. For this purpose, one primer pair was selected from a highly conserved region of the genome of pestiviruses. Using these primers (PEST 1-PEST 2), DNA fragments of between 72 and 74 bp could be amplified from all pestivirus isolates tested. In order to differe...

Bagheri, Kambiz, Karimi, Mohammad Hosein, Mirzaei, Mitra, Ramzi, Mani, Yaghobi, Ramin,

Background & Objectives: Hepatitis type G virus (HGV) is a flavivirus with RNA genome which has high nucleotide and amino acid similarity with HCV. HGV can infect blood lymphocytes for long period and may have role in inducing or complicating the clinical outcomes in patients with hematological malignancies. Therefore in this study the prevalence of HGV, HCV, and HBV infections were evaluated i...

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