نتایج جستجو برای: haplotyping
تعداد نتایج: 559 فیلتر نتایج به سال:
Hapi is a novel dynamic programming algorithm for haplotyping nuclear families that outperforms contemporary family-based haplotyping algorithms. Haplotypes are useful for mapping and identifying genes which cause and contribute to the etiology of human disease, and for analyzing the products of meiosis to locate recombinations, enabling the identification of recombination hotspots and gene con...
The computation of template matrices is the bottleneck of simple algorithms for perfect phylogeny haplotyping and for perfect phylogeny under mutation and constrained recombination. The fastest algorithms known so far compute them in O(nm) time. In this paper, we describe an algorithm for computing template matrices in O(nm/ log(n)) time. We also present and discuss a conjecture that implies an...
background: breast cancer is the most common malignancy in women. breast cancer type 1 susceptibility gene (brca1) is a tumor suppressor gene, involved in dna damage repair and in 81% of the breast-ovarian cancer families were due to brca1. in some clinically investigated genes, the intragenic marker polymorphism is important and the screening of such mutations is faster by using short tandem r...
MOTIVATION Accurate haplotyping-determining from which parent particular portions of the genome are inherited-is still mostly an unresolved problem in genomics. This problem has only recently started to become tractable, thanks to the development of new long read sequencing technologies. Here, we introduce ProbHap, a haplotyping algorithm targeted at such technologies. The main algorithmic idea...
In recent years, a myriad of new statistical methods have been proposed for detecting associations of rare single-nucleotide variants (SNVs) with common diseases. These methods can be generally classified as 'collapsing' or 'haplotyping' based. The former is the predominant class, composed of most of the rare variant association methods proposed to date. However, recent works have suggested tha...
MOTIVATION Some economically important plants including wheat and cotton have more than two copies of each chromosome. With the decreasing cost and increasing read length of next-generation sequencing technologies, reconstructing the multiple haplotypes of a polyploid genome from its sequence reads becomes practical. However, the computational challenge in polyploid haplotyping is much greater ...
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