In this paper I will present a summary of Turing’s article “Computing machinery and intelligence” [26] and discuss it. I retrace the ideas Turing presented in this paper and explain their historical context. Also, I discuss the impact Turing’s ideas had on the scientific community when the paper was published in 1950 as well as the meaning they still have today. Throughout this paper, I include...

The Mediator complex regulates gene transcription by linking basal transcriptional machinery with DNA-bound transcription factors. The activity of the Mediator complex is mainly controlled by a kinase submodule that is composed of 4 proteins, including MED12. Although ubiquitously expressed, Mediator subunits can differentially regulate gene expression in a tissue-specific manner. Here, we repo...

Abstract Coal mining in China is continually increasing, and the associated emitted coal mine dust of growing environmental occupational concern. In this study, deposited (DD) was analysed three different regions an active, highly-volatile bituminous open-pit Xingjian Province, Northwest China: working fronts, tailings handling sites, road traffic sites. Samples were for particle size, geochemi...

The ever-changing business context requires organisations to constantly adapt their motivation and service representations. While there has been work focusing on the relation between the motivationand service level, very little work has been done in providing machinery for handling (propagating) changes at the motivation level and identifying the resulting impact on the service landscape. In th...

Malaysia’s paddy sector frequently relies on machinery in its activities, from land preparation until harvesting. However, the shortfall of meeting domestic demand, ineffective use machinery, mismanagement, and technical inefficiency were among sector’s challenges. This study analyses socio-economic effect efficiencies Muda Agricultural Development Authority (MADA) Integrated Area Barat Laut Se...

In this study, solutions for machinery layout with the aim of reducing transportation costs will be discussed. To do this, imperialist competitive algorithm (ICA), which is a very complicated and effective meta-heuristic algorithm is introduced. In the offered algorithm, different kinds of machinery layout are considered in single-row as country and then the best possible layout is developed ba...

The development of appropriate health and safety interventions for farmers and agri-workers is important world-wide but data on present practices and attitudes to change are lacking. A representative quota sample (n = 1,938) of the Irish population was surveyed on lifestyle practices and workplace risk assessment and control measures, in relation to chemical exposure, manual handling and machin...

Large companies use a lot of resources on workshop operator training and industrial machinery maintenance since the lack this practice or its poor implementation increases cost risks operating handling sensitive and/or hazardous machinery. Industrial Augmented Reality (IAR), major technology in Industry 4.0 paradigm that may enhance worker performance, minimize hazards improve manufacturing pro...

Excitation-contraction coupling in cardiac myocytes requires calcium influx through L-type calcium channels in the sarcolemma, which gates calcium release through sarcoplasmic reticulum ryanodine receptors in a process known as calcium-induced calcium release, producing a myoplasmic calcium transient and enabling cardiomyocyte contraction. The spatio-temporal dynamics of calcium release, buffer...

Systems biology seeks not only to discover the machinery of life but to understand how such machinery is used for control, i.e., for regulation that achieves or maintains a desired, useful end. This sort of goal-directed, engineering-centered approach also has deep historical roots in developmental biology. Not surprisingly, developmental biology is currently enjoying an influx of ideas and met...