Bioactive 3-alkylpyridinium polymers (poly-APS) have recently been isolated from the marine sponge Reniera sarai. Previous results have shown that these molecules in aqueous solutions form supramolecular aggregates with an average hydrodynamic radius of 23 +/- 2 nm. To obtain additional evidences about the shape and the dimensions of poly-APS aggregates, we used atomic force microscopy (AFM) op...

The assignment of the absolute configuration chiral compounds critically depends on comparison with predictions chiroptical spectra intrinsically inaccurate quantum chemical calculations. Wybren Jan Buma, Valentin Paul Nicu et al. report in their Research Article (e202307053) a novel protocol based genetic algorithm analyses and hierarchical clustering that overcomes these inaccuracies as demon...

The assignment of the absolute configuration chiral compounds critically depends on comparison with predictions chiroptical spectra intrinsically inaccurate quantum chemical calculations. Wybren Jan Buma, Valentin Paul Nicu et al. report in their Research Article (e202307053) a novel protocol based genetic algorithm analyses and hierarchical clustering that overcomes these inaccuracies as demon...

The c-AMP dependent protein kinase (PKA) inhibition, haemolytic activity, and cytoxicity of 21 extracts obtained from North Western Australian sponges collected from depths of 84-135 m were investigated. Hexane extracts from Ircinia/Sarcotragus sp. and Geodia sp. displayed PKA inhibitory activities of 100 and 97% respectively (at 100 microg/mL), while aq. methanol extracts from Haliclona sp. ex...

Filtration rate (measured as clearance of algal cells) was measured at different temperatures in the sponge Halichondna panicea. An increase in water temperature from 6 to 12 "C caused the mean flltration rate to increase 4.3 * 2.3 tlmes. Thls value was higher than previously found for other marine ciliary suspension-feeding anlmals. Filtration rate at 12 "C was also measured in Haliclona urceo...

Sponges (Porifera) are one of the most ancestral metazoan groups. They are characterized by a simple body plan lacking the true tissues and organ systems found in other animals. Members of this phylum display a remarkable diversity of form and function and yet little is known about the composition and complexity of their genomes. In this study, we sequenced the transcriptomes of two marine hapl...

Two new long-chain C33 polyacetylenic compounds, halicynones A and B were isolated from the marine sponge Haliclona sp. along with known analogs. The known compound pellynol A possessing a 1-yn-3-ol terminus, exhibited strong antitumor activity against the human colon tumor cell line HCT-116 (IC50 0.026 μg/mL), however, the corresponding 1-yn-3-one, halicynone A, was inactive, which suggests an...

The aim of our research is the screening of extracts of marine sponges for their antifungal activity against phytopathogenic fungi. The in vitro screening of hydroalcoholic and organic extracts of ten marine sponges from Atlantic coast of Morocco against five phytopathogenic fungi (Fusarium oxysporum f.sp. melonis, Fusarium oxysporum f.sp. radicis-lycopersici, Fusarium oxysporum f.sp. ciceris, ...