Purpose: We performed a phase I clinical trial of adenovirus/prostate-specific antigen (PSA) vaccine in men with measurable metastatic hormone-refractory disease. Experimental Design: Men with measurable metastatic disease received one vaccine injection. Toxicity, immune responses, changes in PSA doubling times, and patient survival were assessed. Thirty-two patients with hormone-refractory met...

In three studies we consider a basis for inter-group helping. Specifically we show that group members may help others in order to disconfirm a stereotype of their own group as mean. Study one shows that Scots believe they are seen as mean by the English, resent this stereotype, are motivated to refute it, and believe out-group helping is a particularly effective way of doing so. Study two shows...

Open AccessJournal of UrologyAdult Urology1 Aug 2021Indirect Comparison Darolutamide versus Apalutamide and Enzalutamide for Nonmetastatic Castration-Resistant Prostate Cancer Susan Halabi, Shan Jiang, Emi Terasawa, Viviana Garcia-Horton, Rajeev Ayyagari, A. Reginald Waldeck, Neal Shore HalabiSusan Halabi http://orcid.org/0000-0003-4135-2777 Duke University, Durham, North Carolina Fellow the Am...

A distributed GA is designed for the packet switched network routing problem under minimal information. The requirements of such a problem mean that agents are required to possess more intelligence than was previously the case. To this end a distributed GA approach is developed and benchmarked against the AntNet algorithm under the same information constraints. 1 GENERAL FORMATTING INSTRUCTIONS...

This clinical guideline from the American Society for Gastrointestinal Endoscopy (ASGE) provides an evidence-based approach management of patients with malignant hilar obstruction (MHO). document was developed using Grading Recommendations Assessment, Development and Evaluation framework addresses primary drainage modality (percutaneous transhepatic biliary [PTBD] vs endoscopic [EBD]), strategy...

While localised prostate cancer can be cured by local treatment, ‘high-risk’ often progresses to castration resistant disease and remains incurable with a dismal prognosis. In recent years, technical advances development of novel methodologies have largely contributed better understanding underlying molecular mechanisms that promote tumour growth progression. Consecutively, therapeutic strategi...

•The siRNA micelleplexes were designed for turning “cold” tumors into “hot” ones•Tumor-microenvironment-responsive nanomaterial precise drug delivery•Normalize the tumor vasculature to enhance oxygen-dependent photoimmunotherapy It is highly desirable turn ones improve efficacy of antitumor immunotherapy. Photoimmunotherapy can induce immunogenic cell death (ICD), providing a new path pursue th...

extended abstract 1. introduction abbasid period can be regarded as an epoch in which poetry and eulogy in persia reached maturity, i.e., in which poetry has become a means of praise and admiration (dayf, 2006, p. 565). the kings of this dynasty gathered a group of flattered eulogists and used them for political announcements (alebadi, 2006, p. 13), by allocating precious gifts of war booty to ...

At FDA as well as industry, we promote powerful test with type I error rate controlled. It leads to various tests using different standard error or confidence interval. We often ignored that the confidence interval should be consistent with the test. It happens also often in equivalence testing when 90% confidence interval is used to decide if the two treatments are equivalent. I examined cases...

In two experiments we explored how learning from traditional molar worked-out examples focusing on problem categories and their associated overall solution procedures as well as from more efficient modular worked-out examples where intrinsic cognitive load is reduced by breaking down complex solutions into smaller meaningful solution elements can be further enhanced. Instructional explanations ...