Linum spp. (Linaceae) has been shown to accumulate cytotoxic lignans such as podophyllotoxin and 6-methoxypodopyllotoxin. Therefore, plant cell and tissue cultures of Linum spp. may be possible alternative sources for the lignan production. In this study, we focused on the production of lignans by root cultures of Linum spp. Hairy root cultures of L. nodiflorum, L.album and L. austriacum and ro...

BACKGROUND The introduction of new treatments for hairy cell leukemia has resulted in improved patient survival but also engendered increasing concern about the possibility of excess second cancers. The available evidence is conflicting, with most risk estimates based on sparse numbers. To our knowledge, no study has evaluated cause-specific mortality in patients with hairy cell leukemia. MET...

Background and objectives: Silymarin is a unique flavonoid complex with documented hepatoprotective properties. Silybum  marianum hairy root culture as a source for producing silymarin has been an important strategy for study the cell signaling pathway. In the present investigation Trichoderma strains- Silybum marianum hairy root cultures interactions have been studie...

Abbreviations: DLBL, diffuse large B-cell lymphoma; FL, follicular lymphoma; MALT, MALT type lymphoma; MCL, mantle cell lymphoma; NMZL, nodal marginal zone B-cell lymphoma; PCR, polymerase chain reaction; SLL, small lymphocytic lymphoma; WHO, World Health Organization. sentation of hairy cell leukemia: a case series of four clinically unsuspected cases. Indian J Hematol Blood Transfus 2014;30(S...

Hairy-cell leukaemia is a rather uncommon chronic malignant lymphoproliferative disorder accounting for about 2% of all adult leukaemia cases [1]. This clonal B-cell proliferation [2] is characterized by a cellular infiltration of both bone marrow and spleen by large differentiated B cells, often exhibiting hair-like protrusions (hairy cells). We report here the first case of hairy-cell leukaem...

Members of the widely conserved Hairy/Enhancer of split family of basic Helix-Loop-Helix repressors are essential for proper Drosophila and vertebrate development and are misregulated in many cancers. While a major step forward in understanding the molecular mechanism(s) surrounding Hairy-mediated repression was made with the identification of Groucho, Drosophila C-terminal binding protein (dCt...

The diagnosis of hairy cell leukemia was made in three patients by phase-contrast microscopy and histochemistry of the abnormal peripheral blood cells. Both IgM and IgD surface immunoglobulins were resynthesized after these cells were trypsinized and cultured. Aggregate or Fc receptors were demonstrated on hairy cells. The ability to phagocytose latex was also a property of hairy cells; however...

Hairy B-cell lymphoproliferative disorder (HBLD) is one of chronic polyclonal B-cell lymphocytosis. We report a 47-year-old female Japanese patient diagnosed as having HBLD based on lymphocytosis with hairy cell appearance and characteristic phenotypes including CD11c+ and without B-cell monoclonality. She was a non-smoker and possessed HLA-DR4. She has been closely followed up without treatmen...

BACKGROUND We previously reported ongoing mutational and isotype switch events in the immunoglobulin (Ig) heavy chain (H) locus in hairy cell leukemia. Those analyses raised questions on the incidence and type of selective influences occurring on the tumor B-cell receptor of hairy cell leukemia. DESIGN AND METHODS To further investigate this issue, we examined the full IGH and kappa and lambd...