A technique for genetic modification of hair follicles was developed which results in efficient alteration of the hair shaft phenotype. High-level in vivo transgene expression was maintained in hair follicles such that growing hair shafts were phenotypically altered. Mouse anagen skin fragments, maintained in histoculture, were genetically modified at high efficiency with adenoviral-GFP. The hi...

Advances in RNA sequencing technology allow for potential applications in areas of personal genomics and molecular diagnostics. However, a rate-limiting step of widespread analysis of the transcriptome is the restricted access to viable tissue samples. The hair follicle is an actively regenerating mini organ and the hair shaft is the output of this organ. Here we report on the discovery of hair...

Hair shaft disorders encompass a wide range of hair defects with or without fragility, which could be acquired inherited genetically. may localized generalized and are characterized by changes in color, structure, length, density. Pili torti, also called twisted hair, is clinical entity the flattened 180° along its axis. annulati described as striped showing alternate light dark bands. Trichorr...

We presented RGB video microscopic system for in vitro monitoring of optical properties of hair shaft and follicle and experimental results ofstudy ofthe hair optical and geometrical properties using RGB analysis technique.

cGVHD: chronic graft-vs-host disease HSCT: hematopoietic stem cell transplant INTRODUCTION Pili torti is a term that originates from Latin (pili meaning hair, torti meaning twisted) used to describe the irregularly flattened and twisted appearance of hair shafts on microscopic hair mount evaluation. Clinically, affected patients have fragile, coarse, and sparse hair. The 1808 rotation along the...

UNLABELLED Over the years, different kinds of hair transplantation have been compared in an attempt to overcome male pattern alopecia and, at the same time, maximize both the survival and growth rate of grafted hair. In this study, we have assessed the survival and growth rate of follicular units (FU) in an in vitro model, as compared with that of conventional hair micrografts, to experimentall...

Observation: Olmsted syndrome (OS) is a very rare genetic disorder, which includes diffuse alopecia, leukokeratose of oral mucosa, onychodystrophy , hyperkeratotic linear streaks, follicular keratosis and anhidrosis. Pseudomonilethrix shaft anomaly is characterized by hair shafts with elliptical nodes at variable intervals and separated by narrower internodes. To the best of our knowledge, we p...

Trichomycosis (trichobacteriosis) is an asymptomatic superficial bacterial colonization of the hair shaft that is clinically characterized by pale yellowish, reddish or blackish sticky, cylindrical concretions surrounding the hair shaft in the axillary or pubic region. As far as we know, the first and only case of trichomycosis capitis was reported in a 8-year-old boy in 2011. We encountered no...

White piedra is a superficial fungal infection of the hair shaft, caused by Trichosporon beigelii . We report two cases of white piedra presenting as brown palpable nodules along the hair shaft with a fragility of scalp hairs. T. beigelii was demonstrated in hair culture of both the patients and T. ovoides as a species was confirmed on carbohydrate assimilation test. The first patient responded...

A 5-year-old female, known case of pachyonychia congenita, presented with diffuse hair loss; remaining hairs were easily plucked kinky hairs. Hair samples from patient were investigated using a light microscope. The hairs of the patients were mainly anagen hairs and unlike normal plucked anagen hairs, showed keratinization and cornification of their hair bulbs. No specific hair shaft abnormalit...