Erlotinib is a small-molecule tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR). Erlotinib has been used primarily to treat non-small cell lung cancer. In addition to its role in tumor cells, EGFR is also an important regulator of growth and differentiation in the skin and hair. Therefore, EGFR-TKIs have been associated with a number of cutaneous side effects includ...

Hair growth is a highly regulated cyclical process. Immunosuppressive immunophilin ligands such as cyclosporin A (CsA) and FK506 are known as potent hair growth modulatory agents in rodents and humans that induce active hair growth and inhibit hair follicle regression. The immunosuppressive effectiveness of these drugs has been generally attributed to inhibition of T cell activation through wel...

BACKGROUND Follicular lymphomatoid papulosis (LyP) describes a variant of LyP with perifollicular infiltrates and some degree of folliculotropism of CD30(+) atypical lymphocytes. So far, only a few cases of follicular LyP have been described. OBJECTIVE Our goal was to study the clinicopathologic features of follicular LyP in a series of 11 cases (9 male, 2 female; age range 7-78 years, mean a...

Today's gold standard in surgical hair restoration is a procedure known as Follicular Unit Transplantation (FUT). Follicular Unit Transplatation might appear to be a simple outpatient procedure, but a very specific skill set is needed to perform it well. Hair transplantation is a team effort, and each member of the surgical staff must be highly trained in order to achieve the desired cosmetic r...

When examining parchment, it can be difficult to determine the animal species from which a skin was obtained. In order develop reliable and non-invasive method of identification, Anna Di Majo, Carlo Federici, Marco Palma studied hair follicles in parchment medieval Italian manuscripts. Using microscopes transmitted light heat-free optical fibers, they analyzed entire follicular structure each s...

Today's gold standard in surgical hair restoration is a procedure known as Follicular Unit Transplantation (FUT). Follicular Unit Transplatation might appear to be a simple outpatient procedure, but a very specific skill set is needed to perform it well. Hair transplantation is a team effort, and each member of the surgical staff must be highly trained in order to achieve the desired cosmetic r...

Alopecia areata is a tissue-restricted autoimmune disease of the hair follicle, which results in hair loss and baldness. It is often psychologically devastating. The role of T lymphocytes in this disorder was investigated with cell transfer experiments. Scalp explants from patients were transplanted to severe combined immunodeficiency (SCID) mice and injected with autologous T lymphocytes isola...

Today's gold standard in surgical hair restoration is a procedure known as Follicular Unit Transplantation (FUT). Follicular Unit Transplatation might appear to be a simple outpatient procedure, but a very specific skill set is needed to perform it well. Hair transplantation is a team effort, and each member of the surgical staff must be highly trained in order to achieve the desired cosmetic r...

BACKGROUND Extracted partial longitudinal follicular units can be used as complete follicular units to regenerate completely differentiated hair growth. The partial follicular units that remained in the dermis in the donor area can survive and produce hairs. This technique enables us to multiply hair follicles in vivo, while preserving the donor area and therefore is suitable in persons, who ha...

BACKGROUND AND OBJECTIVES Darkening of gray and white hairs occurred in 2 patients with increased exogenous triiodothyronine (T3) due to treatment of myxedema coma in one case and iatrogenic hyperthyroidism in the other. We hypothesized that thyroid hormone may affect the homeostasis of hair follicles. To test our hypothesis and investigate the influence of thyroid hormone on the hair cycle, we...