background: brca1 and brca2 genes have been recognized to be responsible for 20-30% of hereditary breast can­cers and approximately 50% of familial breast and ovarian cancers. therefore, the demand for brca1 and brca2 muta­tion screening is rapidly increasing as their identification will affect medical management of people at increased risk. because of high costs involved in analysis of brca1 a...

background: metastasis and recurrence of colorectal cancer after treatment is attributed to stem cells. the aim of this study was to determine the relationship between the expression of stem cell marker cd166 in colorectal cancer by immunohistochemistry and clinicopathologic parameters.methods: from 2006 to 2012, 121 colectomy specimens of patients with colon cancer that were operated in babol ...

background : cancer stem cells are a subgroup of tumor cells that have the capability for self-renewal and differentiation and are characterized by multiple markers. several studies have been conducted to identify these cells in colorectal cancer, including stem cell marker cd24. this study has evaluatedtheassociation of cd24 expression with clinicopathologic features and survival in an immunoh...

aim : the present study aimed to evaluate the prevalence of positive family history of these cancers in a large population-based sample of tehran province, capital of iran. background : upper gastrointestinal (ugi) cancers (gastric and esophagus cancer) constitute a major health problem worldwide. a family history of cancer can increase the risk for developing cancer and recognized as one of th...

background: the incidence rate of esophageal squamouse cell cancer (escc) in eastern part of golestan province in iran is among the highest ones in the world. in order to discover the factors interplay in high rate of escc incidence, several case-control and cross-sectional studies were established in this area.as a cohort study has priority in detecting risk factors of a disease, a 10-year pro...

breast cancer is the most important and prevalent cancer in women that can be managed if detected in the early stages. recently, there has been much focus on the use of epigenetic changes such as dna methylation in early detection of cancer. as recent research has put forth dok7 cpg island methylation as an epimarker, in the present study, using a quantification method, a cohort of iranian spor...

background: transvaginal ultrasound is one of the most common means to examine endometrial cavity lesions although its negative results are more valuable. saline sonohysterography can reduce the number of false negative rates of endometrial lesions diagnoses in tamoxifen consumers. the objective of this study was to determine the diagnostic values of saline infusion sonohysterography (sis) and ...

background: it is suggested that various forms of tobacco use have some effects on diverse sites of head and neck to develop cancer. material and methods: the study examines data for oral cancer in male subjects, collected from the population registered in cancer registry during the year 2007- 2008. all the data collected were entered into the spreadsheets. the statistical package for social sc...

stem cell based treatments are being increasingly explored for their possible potential to treat various cancers. mesenchymal stem cells believed to possess anti-tumor potential and are preferred for their properties like immune privileged nature, ability to migrate to the site of tumor and capability for multilineage differentiation. this tumor tropism property of mscs could be utilized to del...

background: the sentinel lymph node (sln) is defined as the first chain node in the lymphatic basin that receives primary lymphatic flow. if the sln is negative for metastatic disease, then other nodes are expected to be disease-free. sln techniques have been extensively applied in the staging and treatment of many tumors, including melanoma, breast and vulvar cancers. this study aims to evalua...