Nonstationary signals appear often in real-life applications and many of them can be modeled as polynomial phase signals (PPS). High-order ambiguity function (HAF) was rst introduced to estimate the parameters of a single component PPS. But due to its high nonlinearity, HAF has not been widely used for multi-component PPS which appear for example, in Doppler radar applications when multiple tar...

Extracellular H(+) has been hypothesized to mediate feedback inhibition from horizontal cells onto vertebrate photoreceptors. According to this hypothesis, depolarization of horizontal cells should induce extracellular acidification adjacent to the cell membrane. Experiments testing this hypothesis have produced conflicting results. Studies examining carp and goldfish horizontal cells loaded wi...

REGOTORI study is a phase 1b/2 clinical trial for MSI-L/MSS/pMMR refractory metastatic colorectal cancer (mCRC). Our group previously reported that regorafenib plus toripalimab as later line therapy can improve efficacy and survival of mCRC patients (REGOTORI study). In this study, we did exploratory research on tumor plasma samples to provide potential biomarkers may affect the combination the...

Secretion in blowfly salivary glands is induced by the neurohormone serotonin and powered by a vacuolar-type H(+)-ATPase (V-ATPase) located in the apical membrane of the secretory cells. We have established a microfluorometric method for analysing pH changes at the luminal surface of the secretory epithelial cells by using the fluorescent dye 5-N-hexadecanoyl-aminofluorescein (HAF). After injec...

Hypoxia is a strong stimulus for the transcription of a set of genes, including erythropoietin and vascular endothelial growth factor. Here we report on the cloning, functional significance, and expression of a complementary DNA (cDNA) that is involved in hypoxia-mediated expression of these 2 genes. The full-length cDNA encodes a predicted protein of 806 amino acids that contains a leucine zip...

We examined the characteristics of fiber fuse propagation in hole-assisted fibers (HAF). The fiber fuse propagated in the same way as in conventional single-mode fiber (SMF) when the diameter of an inscribed circle linking the air holes (c) was much larger than the diameter of the melted area (Dmelted). The melted area is caused by fiber fuse propagation and Dmelted is assumed to be almost the ...

The spin-half Heisenberg antiferromagnet (HAF) on the square and triangular lattices is studied using the coupled cluster method (CCM) technique of quantum many-body theory. The phase relations between different expansion coefficients of the ground-state wave function in an Ising basis for the square lattice HAF is exactly known via the Marshall-Peierls sign rule, although no equivalent sign ru...

The hepatic arterial buffer response (HABR) effectively controls total blood perfusion in normal livers, but little is known about blood flow regulation in cirrhosis. We therefore studied the impact of HABR on blood perfusion of cirrhotic livers in vivo. After 8-wk CCl(4) treatment to induce cirrhosis, 18 anesthetized rats (and 18 noncirrhotic controls) were used to simultaneously assess portal...

Haf?za çal??malar?na yeme?i eklemek, insan?n yeme?indeki tarihsel bilgileri aç??a ç?karmak g?da haf?zas? çal??malar?n?n temelini olu?turmaktad?r. Bu çal??man?n amac?, göç sonras?nda yemek al??kanl?klar?n?n durumunu anlamak, haf?zas?n? ve kültürel haf?zay? inceleyebilmektir. amaçla Erzincan’?n da? köylerinden ?stanbul’a etmi? 58-83 ya?lar? aras?nda 4 kad?n erkek toplam 8 ki?i ile derinlemesine g...

The method of Hybrid Adaptive Filtering (HAF) aims to recover the recorded electric field signals from anomalies of magnetotelluric origin induced mainly by magnetic storms. An adaptive filter incorporating neuro-fuzzy technology has been developed to remove any significant distortions from the equivalent magnetic field signal, as retrieved from the original electric field signal by reversing t...