To explore a spatiotemporally controllable gene delivery system with high efficiency and safety, polyelectrolyte multilayer (PEM) films were constructed on titanium or quartz substrates via layer-by-layer self-assembly technique by using plasmid deoxyribonucleic acid-loaded lipopolysaccharide-amine nanopolymersomes (pNPs) as polycations and hyaluronic acid (HA) as polyanions. pNPs were chosen b...

Numerous previous studies have established that the addition of a microphase-ordered AB diblock copolymer to a thin homopolymer A (hA) film can slow, if not altogether prevent, film rupture and subsequent film dewetting on a hard substrate such as silica. However, only a few reports have examined comparable phenomena when the hA/AB blend resides on a soft B-selective surface, such as homopolyme...

this article describes the preparation and analysis of nano hydroxyapatite (ha) films on stainless steel 316l through sol-gel technique. the process started with preparation of a nitrate and phosphate sol. after aging the sol for 24 h at room temperature a ss316 substrate was dip-coated and heat-treated at 350 to 450 °c for different times in air. the coating phase and structure on substrate we...

background: titanium (ti) implants are commonly coated with hydroxyapatite (ha). however, ha has some disadvantages such as brittleness, low tensile strength and fracture toughness. it is desirable to combine the excellent mechanical properties of zro2 and the chemical inertness of al2o3 with respect to the purpose of this project which was coating ti implants with ha-zro2-al2o3 to modify the s...

An antiadhesion barrier membrane is an important biomaterial for protecting tissue from postsurgical complications. However, there is room to improve these membranes. Recently, carboxymethylcellulose (CMC) incorporated with hyaluronic acid (HA) as an antiadhesion barrier membrane and drug delivery system has been reported to provide excellent tissue regeneration and biocompatibility. The aim of...

BACKGROUND Auto-crosslinked polysaccharide hyaluronan-based solution (Hyalobarrier-gel) prevents postoperative adhesions. However, its effect on tumour growth is still unknown. The aim of the present study was therefore to investigate the impact on survival of intra-abdominally administered Hyalobarrier-gel, native hyaluronan (HA) and hyaluronan/carboxymethylcellulose (HA/CMC), after intraperit...

Ferroe lectri c Pb(Zr,Ti)O, (PZT) thin films ha ve been fa bri cated by the alkoxide based so l-ge l method. PZT stoc k so lutions ha ve been spin coated on glass. sili con and metalli sed sil ico n substrate. The coating is repeated until 0.6 ~lIn thick ness of film has been deposited on various substrates. PZT thin films have been an ne led at vari ous temperatures and characte rized by X-ray...

PURPOSE Postoperative adhesion is the most frequent complication of abdominal surgery. Therefore, we investigated the individual effects of synthetic barrier [hyaluronic acid/carboxymethylcellulose (HA/CMC)] and pharmacologic agents [low molecular weight heparin (LMWH) cyclo-oxygenase-2 inhibitor (COX-2 inhibitor)] using animal model of intra-abdominal adhesion. MATERIALS AND METHODS The cecu...