Pelet merupakan sistem multipartikulat yang memiliki distribusi ukuran partikel 0,5 – 1,5 mm denganmetode ekstrusi sferonisasi. Keunggulan pelet adalah sifat alir baik, dan porositas rendah.Sediaan akan dibuat minuman dengan bahan dasar ekstrak katuk. Katuk (Suaropus androgynus L)umum dikonsumsi masyarakat sebagai sayuran, karena bermanfaat laktagoga atau pelancar ASI.Pembuatan katuk PVP K30, s...

Solid dispersions (SDs) of ursolic acid (UA) were developed using polyvinylpyrrolidone K30 (PVP K30) in combination with non-ionic surfactants, such as D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) or poloxamer 407 (P407) the aim enhancing solubility and vitro release UA. SDs investigated a 24 full factorial design, subsequently selected formulations characterized for water solubilit...

The main objective of the current study was to formulate poorly water soluble drug Spirinolactone by using solid dispersion technique in order to achieve a better dissolution rate which would further help in enhancing oral bioavailability. Solid dispersions were prepared using two methods; solvent method and fusion method. Solid dispersion was prepared by using polymers, such as Hydroxy propyly...

This study was designed to determine the isolation rate, serovars and biochemical profiles of e. coli from cases of colibacillosis and dead-in-shell embryos in Zaria-Northern Nigeria. The isolation rate of e. coli from hatcheries studied were 4.67% and 7.50% from farms of Simtu Agricultural Company and National Animal Production Research Institute (NAPRI) Shika Zaria, Nigeria respectively. Twen...

The high-affinity iron assimilation system of plasmid ColV-K30 was cloned on the vector plasmid pPlac. Plasmid pABN1 was isolated by means of sensitivity to cloacin, a bacteriocin using the same outer membrane receptor as ferric aerobactin. Restriction maps were determined for this plasmid and for a subclone, pABN5. Plasmid pABN1 codes for the complete gene complex, whereas plasmid pABN5 encode...

Solid dispersions in water-soluble carriers have attracted considerable interest as a means of improving the dissolution rate, and hence possibly bioavailability, of a range of hydrophobic drugs. The poor solubility of carvedilol leads to poor dissolution and hence variation in bioavailability. The purpose of the present investigation was to increase the solubility and dissolution rate of carve...

The aim of this work was to develop cefdinir solid dispersions (CSDs) prepared using hydrophilic polymers with enhanced dissolution/solubility and in vivo oral bioavailability. CSDs were prepared with hydrophilic polymers such as hydroxypropyl-methylcellulose (HPMC; CSD1), carboxymethylcellulose-Na (CMC-Na; CSD2), polyvinyl pyrrolidone K30 (PVP K30; CSD3) at the weight ratio of 1:1 (drug:polyme...

We developed a step-by-step experimental protocol using differential scanning calorimetry (DSC), dynamic vapour sorption (DVS), polarized light microscopy (PLM) and a small-scale dissolution apparatus (μDISS Profiler) to investigate the mechanism (solid-to-solid or solution-mediated) by which crystallization of amorphous drugs occurs upon dissolution. This protocol then guided how to stabilize ...

Cinnamon bark (Cinnamomum burmannii) is used traditionally and has an ingredient containing cinnamic acid compounds. Colocasia esculenta (L) Schott leaves contains of flavonoids, alkaloids, tannins, saponins, steroids, terpenoids. Both the plants C. burmannii have potential as anti-diabetics because they can lower blood glucose levels. This study aims to make combination tablets extract with va...

Objective: The objective of the present work was to formulate solid dispersions simvastatin for enhancement its aqueous solubility and dissolution rate.
 Methods: In study, were prepared by Kneading Solvent evaporation methods. polymeric carriers like Polyethylene glycol (PEG) 6000 Polyvinyl Pyrrolidone (PVP) K30 used in different ratios (ratio drug: carrier 1:1, 1:2) dispersions. characte...