In order to study the interaction of glutathione, vitamin C and vitamin E under hyperoxia (95 % oxygen) and hyperbaric oxygen (2.5 atmospheric pressure), 20 days old male Guinea pigs were fed with basal vitamin C free diet, while receiving a vitamin C supplement of either high concentration (50 mg/day) or low concentration (1 mg/day) for two weeks. Animals were than exposed to hyperoxia and hyp...

there is documented evidence that infection in laboratory animals can often influence the outcome of experiments. all infections, apparent or inapparent, are likely to increase biological variability. as a research project concerning the diversity and distribution of parasites of rabbit and guinea pig in a conventional laboratory animal house, about 87 rabbits (from 700 ) and 105 guinea pigs (f...

in this study, twenty-five strains of mycobacterium tuberculosis resistant to isoniazid (inh) were isolated from patients with tuberculosis (tb). nine strains (36%) were found to be virulent in guinea-pigs [root index virulence (riv» 1 ]. the remaining sixteen strains (64%) were non-virulent (riv <1). of the nine strains resistant to inh as well as virulent to guinea-pigs, eight of them were fo...

Background: Postoperative peritoneal adhesion bands are one of the most common complications caused by foreign material.  Objective: To investigate the effect of colchicine on talc-induced peritoneal adhesion bands. Method: Adhesion bands were induced in 30 short hair England Guinea pigs by introduction of talc-saline solution (10 mL, 10%) into the peritoneal cavity.  Afterwards, the pigs were ...

background : animal models have been proven useful in elucidating the details of interaction between pathogenic bacteria and their human hosts, in addition to assessing the efficacy of therapeutic compounds and vaccines. in this study, we investigate the colonization of helicobacter pylori ( h. pylori ) in experimentally-infected guinea pigs over a six-month period. materials and methods: a bac...

  The immunogenicity of ten different formulations of intranasal diphtheria and tetanus vaccines which containing different absorption enhancers, adjuvants and other excipients were determined in guinea pigs by the serum neutralization (SN) method. From these ten formulations, it was selected four formulations which gave significant immunogenicity in guinea pigs. In order to design the "final f...

In this study, twenty-five strains of Mycobacterium tuberculosis resistant to isoniazid (INH) were isolated from patients with tuberculosis (TB). Nine strains (36%) were found to be virulent in guinea-pigs [root index virulence (RIV» 1 ]. The remaining sixteen strains (64%) were non-virulent (RIV <1). Of the nine strains resistant to INH as well as virulent to guinea-pigs, eight of them wer...

The purpose of this study was to determine the therapeutic efficacy of citric and tartaric acids on experimental dermatophytosis in guinea pigs. In this study, the susceptibility of Trichophyton mentagrophytes var. mentagrophytes to citric and tartaric acids was assessed using the macrodilution broth method. In the animal experiments, a cream consisting of the mixed acids was topically applied ...

Asthma is a chronic inflammatory disorder of the airways. The available treatment options have major limitations owing to low efficacy, associated adverse events and compliance issues. Therefore, the health burden of bronchial asthma is increasing globally at an alarming rate, providing a strong impetus for the development of new therapeutics. Onosma bracteatum ( O. bracteatum ) is know...

We have examined the capacity of a live avirulent mutant form of the intracellular bacterial pathogen Legionella pneumophila to induce immune responses and protective immunity in guinea pigs. The mutant L. pneumophila is nonlethal to guinea pigs and does not revert to virulence with passage through guinea pigs. In contrast, exposure of guinea pigs to aerosols containing wild-type L. pneumophila...