The tridecapeptide neurotensine has been the subject of increased interest since its discovery and characterization in the brain1). Aspects of its pharmacology include physiological effects both in the periphery and the central nervous system2). In order to elucidate further its pathophysiological role, neurotensin agonists and antagonists are needed. In the course of our screening program to f...

In order to produce antibodies for the radioimmunoassay of cholecystokinin the following animals were immunized: 10 rabbits and 3 guinea pigs with cholecystokinin 1—33 coupled to bovine serum albumin, 9 rabbits and 2 guinea pigs with uncoupled cholecystokinin 1-33, 5 rabbits with cholecystokinin 10-20 coupled to bovine serum albumin and 4 rabbits with sulphated cholecystokinin 26-33 coupled to ...

  Protection of animals immunized against Bacillus anthracis is usually demonstrated by challenging with an appropriate dose of a strain of Bacillus anthracis that is lethal to unvaccinated animals inoculated at the same time. In this study the protective efficacy in anthrax vaccine (34F2 sterne strain spore) was evaluated in sheep, goats and guinea pigs challenged with subcutaneous inoculation...

Trimellitic anhydride (TMA) is one of many low molecular weight compounds known to cause occupational asthma. In our previous studies the TMA-induced allergic response in guinea pigs was attenuated by depletion of complement. Specifically, the leakage of red blood cells and infiltration of inflammatory cells into the lung after TMA challenge was significantly reduced. Thus, we hypothesize that ...

A number of studies have suggested that attentional control skills required to perform 2 tasks concurrently become impaired with age (A. A. Hartley, 1992; J. M. McDowd & R. J. Shaw, 2000). A. A. Hartley (2001) recently observed that the age-related differences in dual-task performance were larger when the 2 tasks required similar motor responses. The present study examined the extent to which a...

Dietary fat saturation has been shown to affect hepatic apoB/E receptor expression and to modify low density lipoprotein (LDL) composition and density in guinea pigs. The current studies were designed to investigate the independent and interactive effects of dietary fat saturation alterations in apoB/E receptor expression and LDL composition on in vivo LDL turnover kinetics, both receptor-media...