A novel oral Hsp90 inhibitor, NVP-HSP990, has been developed and characterized in vitro and in vivo. In vitro, NVP-HSP990 exhibits single digit nanomolar IC50 values on three of the Hsp90 isoforms (Hsp90a, Hsp90b, and GRP94) and 320 nanomolar IC50 value on the fourth (TRAP-1), with selectivity against unrelated enzymes, receptors, and kinases. In c-Met amplified GTL-16 gastric tumor cells, NVP-...

Perubahan dimensi jaringan lunak dan tulang paska pencabutan gigi dapat menyebabkan perubahan estetika wajah. Hal ini disebabkan karena berfungsi untuk mendukung otot wajah, tanpa dukungan wajah terlihat berkerutdan lebih tua. yang pada meliputi lipatan nasolabial menjadi dalam, sudut mulut turun, bibir menipis, atas panjang hidung besar akibat hilangnya atas. Usaha dilakukan memperbaiki keadaa...

New product development (NPD) is both an opportunity and a great challenge for all enterprises, especially those in traditional industries. Enterprises must coordinate well with knowledge from internal external, such as marketing, sales, research development. This study was conducted the aim of clarifying impact management capability on new bamboo painting enterprises Vietnam. In addition, this...

Anthropogenic factors are undoubtedly causing damages to the world’s natural resources and disruption ecosystem services. As an offshoot of government interventions, sustainable development principle was placed at core every undertaking. This heightened environmental awareness created huge impact organizations as pro-environmental behaviors become a prevalent norm. Apparently, Government-Owned ...

During the last years, the aviation sector has been looking into alternatives to kerosene from crude oil, to combat climate change by reduction of greenhouse gas (GHG) emissions and to ensure security of supply at affordable prices. The efforts are also a reaction to commitments and policy packages. Currently, a wide range of possible fuel candidates and fuel blends are discussed in the triple ...

Graph-based Transductive Learning (GTL) is a powerful tool in computer-assisted diagnosis, especially when the training data is not sufficient to build reliable classifiers. Conventional GTL approaches first construct a fixed subject-wise graph based on the similarities of observed features (i.e., extracted from imaging data) in the feature domain, and then follow the established graph to propa...

OBJECTIVE To quantify the FHL length difference obtained through a single approach and by a double combined approach. METHODS 16 fresh cadavers, a total of 32 feet, were used to measure the FHL graft length. With the cadaver positioned in ventral decubitus, a posteromedial incision in the ankle and a second incision in the plantar cavus were performed. RESULTS The average gain of tendon's l...

Abstract: Tooth loss experienced by elderly can be alleviated with complete denture usage. Good hygiene behaviour is achieved due to effective instructions from dentists. Generally, are given verbally or written but they often ineffective misunderstanding being forgotten patients. Educational video method used dentists enhance the instructions. This study aimed determine effect of through educa...

Currently, sustainable business performance has become the global requirement due to recent economic disaster, and green measures have been considered leading solution for it. This situation gained attention of literature regulators; thus, present study examined transformational leadership (GTL), human resource management (HRM), innovation on manufacturing organizations in China. The moderating...