نتایج جستجو برای: gst
تعداد نتایج: 6161 فیلتر نتایج به سال:
Glutathione S-transferases (GST) were characterized from the digestive gland of Cyphoma gibbosum (Mollusca; Gastropoda), to investigate the possible role of these detoxification enzymes in conferring resistance to allelochemicals present in its gorgonian coral diet. We identified the collection of expressed cytosolic Cyphoma GST classes using a proteomic approach involving affinity chromatograp...
Previously we have purified and characterized a major glutathione S-transferase (GST) activity, GST-4a, from the Thai mosquito Anopheles dirus B, a model mosquito for study of anopheline malaria vectors [Prapanthadara, L. Koottathep, S., Promtet, N., Hemingway, J. and Ketterman, A.J. (1996) Insect Biochem. Mol. Biol. 26:3, 277-285]. In this report we have purified an isoenzyme, GST-4c, which ha...
The subcellular distribution of glutathione S-transferase (GST) activity extracted from shoots of 3-day-old etiolated seedlings of maize (Zea mays L., Northrup-King 9283 hybrid) and the induction of soluble and membrane-bound GST activity by the safener benoxacor, the herbicide metolachlor and their combination (CGA-180937) were investigated. GST activity extracted from maize shoots was detecte...
We investigated the impact of glutathione transferases Mu 1 (GSTM1)- and glutathione transferase Theta 1 (GSTT1)-null genotypes on hepatic GST activities in humans and compared the results with those of Gstm1- and Gstt1-null mice. In liver with GSTM1/Gstm1-null genotype, GST activity toward p-nitrobenzyl chloride (NBC) was significantly decreased in both humans and mice. In addition, in liver w...
We have used a rat glutathione S-transferase P (GST-P) complementary DNA as a probe to screen a human placenta complementary DNA library constructed in the lambda gt11 vector. One of the positive clones contained the complete coding region (630 base pair) and the entire 3'-noncoding region (78 base pair) of the putative human glutathione S-transferase pi (GST-pi) subunit mRNA. From the nucleoti...
Two glutathione S-transferase (GST) isozymes, A1/A1 and B1/B2, were purified from etiolated, O-1,3-dioxolan-2-yl-methyl-2,2,2, -trifluoro-4'-chloroacetophenone-oxime-treated sorghum (Sorghum bicolor L. Moench) shoots. GST A1/A1, a constitutively expressed homodimer, had a subunit molecular mass of 26 kD and an isoelectric point of 4.9. GST A1/A1 exhibited high activity with 1-chloro-2, 4, dinit...
Glutathione S-transferases (GSTs) conjugate activated xenobiotics with glutathione; thus, GST induction may improve detoxification and excretion of potentially harmful compounds. Using a randomized cross-over design, we tested the hypothesis that, in humans, serum GST-alpha concentration (GST-alpha) and GST activity increase with vegetable consumption and that this effect is GSTM1 genotype depe...
زمینه و هدف: لیومیوم های رحمی شایع ترین تومور خوش خیم رحمی در زنان می باشد که تقریبا 40-20 درصد زنان در سن باروری به این بیماری مبتلا می باشند. استروژن نقش مهمی در پاتوژنز لیومیوما ایفا می کند. از جمله ژن های درگیر در بیوسنتز استروژن گلوتاتیون s- ترانسفراز می باشد. هدف از این مطالعه بررسی ارتباط میان پلی مورفیسم gstp1 ile105val و خطر ابتلا به لیومیوم رحمی در جمعیت ایرانی بود. روش بررسی: این مطا...
the aim of this study is to determine whether there is a role of podoplanin and glutathione s-transferases t1 (gst-t1) expression in laryngeal squamous cell carcinoma. the study was completed with 33 patients and gene expression analysis was performed by qrt–pcr. the podoplanin and gst-t1 expression patterns were analyzed to determine their correlation with clinicopathologic parameters of laryn...
چکیده آنالیز بروز gstm1 در سرم بیماران مبتلا به آندومتریوز زهرا سرخو اندومتریوز یک بیماری زنانه با شیوع و دلایل ناشناخته بالایی است. یک بیماری مزمن که دلیل آن حضور بافت آندومتریال در موقعیت بیرونی دیواره رحم می باشد. این بیماری به شکل بافتی و با حضور و رشد غدد اندومتریال و استروما در قسمت بیرونی رحم شناخته می شود. زنان مبتلا به این بیماری از دچار علائمی مانند درد مزمن لگن، دیسمنوره...
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