نتایج جستجو برای: gspe

تعداد نتایج: 87  

Journal: :Molecules 2011
Xiaoli Li Xiaolai Yang Yongqing Cai Hong Qin Li Wang Yanhong Wang Yanhui Huang Xiaoxia Wang Shuai Yan Liping Wang Xin Zhao Wan Li Sijia Li Jiajia Chen Yongjie Wu

To elucidate the molecular mechanisms involved in the therapeutic effects of proanthocyanidins from grape seeds (GSPE), we explore whether GSPE regulates the inflammatory response of TNBS-induced colitis in rats at the levels of NF-κB signal transduction pathway. Rats were intragastrically administered of different doses of GSPE (100, 200 and 400 mg·kg-1) per day for seven days after ulcerative...

Journal: :European review for medical and pharmacological sciences 2012
O Zhai N Zhong H Q Gao B Y Li B Jiang

OBJECTIVES In this study, we investigated the effect of grape seed proanthocyanidins extracts (GSPE), which have been proved to have anti-oxidative and anti-aging functions, on the expression of apoA-L at mRNA level of HepG2 cells in vitro under the experimental conditions of high-sugar and sugar. MATERIALS AND METHODS Cell viability was measured by sulforhodamine B (SRB). The apoA-I mRNA exp...

2016
Miao Long Yi Zhang Peng Li Shu-Hua Yang Wen-Kui Zhang Jian-Xin Han Yuan Wang Jian-Bin He

The aim was to investigate the prevention of grape seed proanthocyanidin extract (GSPE) on the subchronic immune injury induced by aflatoxin B1 (AFB1) and the possible ameliorating effect of GSPE in mice. The subchronic AFB1-induced immune injury mice model was set up with the continuous administration of 100 μg/kg body weight (BW) AFB1 for six weeks by intragastric administration. Then, interv...

2010
Cathie M. Pfleger Jun Wang Lauren Friedman Roselle Vittorino Lindsay M. Conley Lap Ho Hayley C. Fivecoat Giulio M. Pasinetti

Drosophila models of tauopathies have been developed by transgenically overexpressing the disease-associated forms of tau. In this paper we report for the first time that a recently developed Grape-Seed Polyphenolic Extract (GSPE) improves the eye phenotype of a Drosophila eye model of R406W tau. GSPE-mediated improvements in this distinct in vivo neurodegeneration model for protein misfolding/...

2016
YAN SUN CAIMEI XIU WEI LIU YUAN TAO JIANRONG WANG YI QU

The present study aimed to investigate whether grape seed proanthocyanidin extract (GSPE) has a protective effect on diabetic retinal function. A total of 30 Wistar rats were randomly divided into three equal groups, including the control, diabetic and GSPE-treated diabetic groups. Retinal tissue was harvested and subsequently stained with hematoxylin and eosin. Superoxide dismutase (SOD), glut...

2013
Tae Ho Kim Eun Jeong Jeon Dae Young Cheung Chang Whan Kim Sung Soo Kim Soo-Heon Park Sok Won Han Myung Jun Kim Youn Soo Lee Mi-La Cho Jae Hyuck Chang Jun Ki Min Jin Il Kim

BACKGROUND/AIMS To investigate the gastroprotective effects of grape seed proanthocyanidin extracts (GSPEs) against nonsteroid anti-inflammatory drug (NSAID)-induced gastric mucosal injury in rats. METHODS Sprague-Dawley rats were randomly allocated to the normal control, indomethacin, low-dose GSPE, high-dose GSPE and misoprostol groups. All groups except the normal control group received pr...

Journal: :iranian journal of pharmaceutical research 0
esrafil mansouri department of anatomical sciences, cellular and molecular research center, faculty of medical sciences, ahvaz jundishapur university of medical sciences, iran layasadat khorsandi department of anatomical sciences, cellular and molecular research center, faculty of medical sciences, ahvaz jundishapur university of medical sciences, iran maasoumeh zare moaiedi laboratory of amir kabir hospital, ahvaz, iran

grape seed proanthocyanidin extract (gspe) has a broad spectrum of biologic properties against oxidative stress. this study aimed to investigate the effects of gspe on biochemical factors and antioxidant enzymes of erythrocyte in diabetic rats. diabetes was induced through single injection of streptozotocin (50 mg.kg-1, i.p). forty male sprague-dawley rats were divided into four groups: group 1...

2015
Aleix Ribas-Latre Laura Baselga-Escudero Ester Casanova Anna Arola-Arnal M-Josepa Salvadó Cinta Bladé Lluís Arola

Metabolism follows circadian rhythms, which are driven by peripheral clocks. Clock genes in the liver are entrained by daytime meals and food components. Proanthocyanidins (PAs), the most abundant flavonoids in the human diet, modulate lipid and glucose metabolism. The aim of this study was to determine whether PAs could adjust the clock system in the liver. Male Wistar rats were orally gavaged...

2013
Lídia Cedó Anna Castell-Auví Victor Pallarès Mayte Blay Anna Ardévol Montserrat Pinent

In a previous study, the administration of a grape seed procyanidin extract (GSPE) in female Wistar rats improved insulin resistance, reduced insulin production, and modulated apoptosis biomarkers in the pancreas. Considering that pharmacokinetic and pharmacodynamic parameters in females are different from these parameters in males, the aim of the present study was to evaluate the effects of GS...

Journal: :Neurobiology of aging 2012
Ismael Santa-Maria Carmen Diaz-Ruiz Hanna Ksiezak-Reding Alice Chen Lap Ho Jun Wang Giulio Maria Pasinetti

Tauopathies are characterized by progressive neurodegeneration caused by intracellular accumulation of hyperphosphorylated tau protein aggregates in the brain. The present study was designed to test whether a grape seed polyphenolic extract (GSPE) previously shown to inhibit tau protein aggregation in vitro could benefit tau-mediated neuropathology and behavior deficits in JNPL3 transgenic mice...

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