Once melanoma metastasizes, no effective treatment modalities prolong survival in most patients. This notorious refractoriness to therapy challenges investigators to identify agents that overcome melanoma resistance to apoptosis. Whereas many survival pathways contribute to the death-defying phenotype in melanoma, a defect in apoptotic machinery previously highlighted inactivation of Apaf-1, an...

BACKGROUND Lung cancers are resistant to conventional chemotherapeutic interventions such as paclitaxel. Notch signaling is crucial in the chemoresistance of lung cancer cells. The Notch inhibitor gamma-secretase inhibitor (GSI) inhibits the Notch signaling pathway. MATERIAL AND METHODS Here, we evaluated how Notch-3 inhibition by GSI can enhance the sensitivity of lung cancer cells to paclitax...

D. Schulz-Ertner, C. Thilmann, M. Wannenmacher, J. Debus Before patient irradiations started in 1997, a radiation unit was built at the heavy ion synchrotron of the GSI and major future directed technical and radiobiological innovations have been implemented. For the first time, tumor conform application of carbon beams was realized by intensity-controlled rasterscanning with pulse-to-pulse ene...

ABSTRACT This study aimed to translate, create a cut-off point, and assess the measurement properties of female genital self-image scale (FGSIS) in Brazilian women. Content, structural, construct validity, internal consistency, test-retest reliability, errors were assessed this online study. FGSIS point classify satisfaction with (GSI) was performed using Partial Credit Model (PCM). In total, 6...

This paper introduces a simple, quantitative assessment tool to follow up the recovery of gait. Today, micro-electro-mechanical systems (MEMS) technology provides with small, simple, low-power consuming and easy to don and doff sensors. In our approach we have selected an accelerometer and introduced a new quantity that characterizes the gait pattern in the frequency domain, we term it Gait Spe...

Drug resistance remains a critical problem in the treatment of patients with multiple myeloma. Recent studies have determined that Notch signaling plays a major role in bone marrow (BM) stroma-mediated protection of myeloma cells from de novo drug-induced apoptosis. Here, we investigated whether pharmacologic inhibition of Notch signaling could affect the viability of myeloma cells and their se...

a total of 48 female spirlins alburnoides sp. from the kesselian stream (south caspian sea basin, northern iran) were examined during a period from july 2008 to june 2009 to obtain data on fecundity, and to determine the spawning season of this carp. the mean absolute fecundity of females spirlin was 1722.92 (653.88) eggs. the fecundity has positive correlation with the size of the female. the...

Feral raccoons (Procyon lotor) have been growing in number in Japan, and they are becoming a problematic invasive species. Consequently, they are commonly captured and killed in pest control programs. For effective population control of feral raccoons, it is necessary to understand their reproductive physiology and ecology. Although the reproductive traits of female raccoons are well known, tho...

PURPOSE Accumulating evidence supports the existence of breast cancer stem cells (BCSC), which are characterized by their capacity to self-renew and divide indefinitely and resistance to conventional therapies. The Notch pathway is important for stem cell renewal and is a potential target for BCSC-directed therapy. EXPERIMENTAL DESIGN Using human breast tumorgraft studies, we evaluated the im...

OBJECTIVE To validate optical coherence tomography (OCT) imaging for assessment of vascular healing in a preclinical animal model and human autopsy cases and to translate the findings to the assessment of vascular healing after drug-eluting stent implantation in clinical practice. APPROACH AND RESULTS Drug-eluting and bare metal stents were imaged 28 and 42 days after implantation in atherosc...