The phosphatidylinositol 3' kinase (PI3K) pathway is commonly activated in breast cancer and aberrations such as PI3K mutations are common. Recent exciting clinical trial results in advanced estrogen receptor-positive (ER) breast cancer support mTOR activation is a major means of estrogen-independent tumor growth. Hence the means to identify a responsive breast cancer population that would most...

Mungbean (Vigna radiata (L.) Wilczek) or green gram as a dryland grain legume is exposed to varied timings and severity of drought stress, resulting in variability in photoassimilate production. In order to evaluate some physiological responses in one mungbean cultivar to timing and severity of drought stress, a 3-replicate RCBD (randomized complete block design) field experiment was carried ou...

Five commercial wheat varieties, namely C 306, HI 977, HW 2004, PBW 550 and WH 542 of diverse baking performances were examined for their physicochemical parameters, gluten quality and HMW-GS composition. All the varieties presented a broad spectrum of different quality parameters.Based on the kernel dimensions, thousand kernel weight and hectolitre weight, WH 542 was observed to have smaller a...

An element a in ring R has gs-Drazin inverse if there exists b ? comm2(a) such that = b2a, ab Rqnil. For any s C(R), we completely determine when generalized matrix A Ks(R) over local inverse.

Purpose: To investigate whether tumor volume derived from apparent diffusion coefficient (ADC)maps (VolumeADC) and tumormeanADCvalue (ADCmean) are independent predictors of prostate tumorGleason score (GS). Experimental Design: Tumor volume andGSwere recorded fromwhole-mount histopathology for 131 men (median age, 60 years) who underwent endorectal diffusion-weightedMRI for local staging of pro...

The present study aimed to integrate evidence on the relationship among broad retrieval ability (Gr), processing speed (Gs), and divergent thinking (DT) with a three-level meta-analytic approach. analysis was conducted 560 effect sizes obtained from 47 studies an overall sample of 10,391 participants. Results indicated moderate mean correlations for both Gr–DT (r = 0.47, 95% CI: [0.38, 0.54]) G...

Insulin and contraction regulate glucose uptake and glycogen synthase (GS) via distinct mechanisms in skeletal muscles, and an additive effect has been reported. Glycogen content is known to influence both contraction- and insulin-stimulated glucose uptake and GS activity. Our study reports that contraction and insulin additively stimulate glucose uptake in rat epitrochlearis muscles with norma...

The aim of this study was to evaluate the association of plasma fibroblast growth factor (FGF)-21 with angiographically significant coronary artery disease (CAD) in patients with type 2 diabetes mellitus. Serum FGF-21 was measured in 120 patients undergoing coronary angiography. Patients were divided into 4 groups based on the presence/absence of type 2 diabetes mellitus and of significant CAD....

OBJECTIVES We aimed to investigate the relationship between myocardial performance index (MPI) and severity of coronary artery disease, as assessed by the Gensini score (GS), in patients with non-ST-segment elevation myocardial infarction (NSTEMI). METHODS Ninety patients with an initial diagnosis of NSTEMI were enrolled in our study. They were divided into tertiles according to the GS: low G...