“Back to nature” is an increased demand nowadays, for using plants in therapy “instead of using synthetic drugs that may have adverse effects. Grape seed extract (Proanthcyanidins) and Selenium possesses a wide array of pharmacological and biochemical actions. Hymenolepiasis and Passulurus infections are considered as common health problems worldwide. In the present study, Grape seed extract an...

Title of Document: ANTIOXIDANT AND ANTIPROLIFERATIVE PROPERTIES OF SELECTED GRAPE SEED EXTRACTS Raquel Zorah Bloom, Master of Science, 2009 Directed By: Associate Professor Dr. Liangli Yu Nutrition and Food Science This study examined chardonnay, muscadine, concord, and ruby red grape seed oil and flour extracts for antioxidant and anti-proliferative properties. The extracts were tested for tot...

Background: The alkylating agent busulfan adversely affects spermatogenesis in mammals and Impairment of spermatogenesis has been identified as an inevitable side effect of cancer treatment druges then the aim of this study was to investigate the possible protective effects of Grape seed extract with potent antioxidant activity, on busulfan-treated adult male mice. Materials and Methods: In thi...

BACKGROUND/AIM Therapeutic interventions in nonalcoholic fatty liver disease are limited, while anti-oxidative materials have shown benefits in animal models. This study aimed to evaluate grape seed extract as an anti-oxidative material in this process. Therapeutic effects of grape seed extract were evaluated in comparison to vitamin C in a double-blind setting. MATERIALS AND METHODS Fifteen ...

PURPOSE To determine the effect of grape-seed extract against ischemia/reperfusion injury in cholestatic liver. METHODS Eighteen Wistar albino rats were divided into three groups. In control and study groups, cholestasis was provided by bile duct ligation. Seven days later, the rats were subjected to 30 min hepatic ischemia, followed by 60 min of reperfusion. Oral administration of 50 mg/kg/d...

Triton WR-1339 administration causes neurotoxicity. Natural products and herbal extracts can attenuate cerebral injury. In the present study, we investigated the neuroprotective role of grape seed extract and/or vitamin B6 against triton-induced neurotoxicity. Thirty-five adult male albino rats of the Sprague-Dawley strain, weighing 140-145 g, were divided into five groups: control, triton, gra...

Proanthocyanidins, compounds highly concentrated in dietary fruits, such as cranberries and grapes, demonstrate significant cancer prevention potential against many types of cancer. The objective of this study was to evaluate cranberry and grape seed extracts to quantitate and compare their anti-proliferative effects on the most common type of oral cancer, oral squamous cell carcinoma. Using tw...

Phenolic compound profiles were investigated by HPLC-MS in two consecutive years to assess genotypic variation in berry skins of nine red Vitis vinifera cultivars. The results showed that the types and levels of phenolic compounds greatly varied with cultivar. Common wine grape cultivars such as Syrah, Cabernet Sauvignon, Cabernet Gernischt and Merlot contained more types of anthocyanins, flavo...

Chloasma (melasma), an acquired hypermelanosis, is often recalcitrant to various treatments and an amenable, as well as safe, pigment-reducing modality is needed. We investigated that the reducing effect of proanthocyanidin, a powerful antioxidant, on chloasma in a one-year open design study. Proanthocyanidin-rich grape seed extract (GSE) was orally administered to 12 Japanese woman candidates ...

The hepatoprotective activity of red grape seed extracts (GSEs) was investigated against ethanol-induced cytotoxicity. In this study, liver slice culture model was used to demonstrate hepatoprotective activity of two GSEs (water and ethanol) in vitro. The hepatoprotective activity was evaluated by measuring the levels of lipid peroxidation, protein carbonyls, lactate dehydrogenase (LDH) leakage...