نتایج جستجو برای: granulopoiesis
تعداد نتایج: 691 فیلتر نتایج به سال:
Inhibitor of DNA binding (Id) proteins function as inhibitors of members of the basic helix-loop-helix family of transcription factors and have been demonstrated to play an important role in regulating lymphopoiesis. However, the role of these proteins in regulation of myelopoiesis is currently unclear. In this study, we have investigated the role of Id1 and Id2 in the regulation of granulopoie...
Epigenetic modifications regulate developmental genes involved in stem cell identity and lineage choice. NFI-A is a posttranscriptional microRNA-223 (miR-223) target directing human hematopoietic progenitor lineage decision: NFI-A induction or silencing boosts erythropoiesis or granulopoiesis, respectively. Here we show that NFI-A promoter silencing, which allows granulopoiesis, is guaranteed b...
Expression of the E3 ubiquitin ligase Triad1 is greater in mature granulocytes than in myeloid progenitor cells. HoxA10 actives transcription of the gene encoding Triad1 (ARIH2) during myeloid differentiation, but the contribution of increased Triad1 expression to granulocyte production or function is unknown. Mice with bone marrow-specific disruption of the ARIH2 gene exhibit constitutive infl...
Polymorphonuclear neutrophil granulocytes (neutrophils) represent a fundamental component of the innate immune system, forming an efficient barrier against invading microbial pathogens. Neutropenia, a common unwanted side effect of chemotherapy, is associated with infectious complications. The human bone marrow produces an estimated number of 10 neutrophils per day, and granulopoiesis physiolog...
The purpose of this study was to describe the microRNA (miRNA) expression profiles of neutrophils and their precursors from the initiation of granulopoiesis in the bone marrow to extravasation and accumulation in skin windows. We analyzed three different cell populations from human bone marrow, polymorphonuclear neutrophil (PMNs) from peripheral blood, and extravasated PMNs from skin windows us...
Granulopoiesis is tightly regulated to meet host demands during both "steady-state" and "emergency" situations, such as infections. The transcription factor CCAAT/enhancer binding protein β (C/EBPβ) plays critical roles in emergency granulopoiesis, but the precise developmental stages in which C/EBPβ is required are unknown. In this study, a novel flow cytometric method was developed that succe...
A computer model simulating granuuse were simulated, resulted in states lopoiesis has been constructed on the resembling cyclical and severe nonbasis of two feedback loops, one concyclical neutropenia, respectively. The trolling the rate of production of granuresults provide evidence that a number locytes at the stem cell level, the other of the periodic features shown by normal controlling the...
introduction: stress has many effects on the development of systems and organs in the fetal period, and these effects appear after birth. since hemopoietic system is susceptible to stress, effects of restraint stress were studied in offspring of pregnant rats. methods: pregnant rats were divided into one control and three stress groups. the control group did not receive any stress during the ge...
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