Farmers lung disease is a common form of hypersensitivity pneumonitis (HP) and is characterized by inflammation and granuloma formation in the lung. Interferon-gamma is important for the expression of granulomatous diseases caused by infectious agents; however, the role this mediator in regulating expression of the granulomatous response to inhaled antigen is not known. To evaluate this, we com...

conclusion gm presents with a wide range of conventional radiological findings, hampering the diagnosis. in patients with inconclusive conventional findings, mri may assist in the differential diagnosis and assessment of the extent of disease. however, a definitive diagnosis and relevant treatment require histopathological confirmation. objectives the aim of this study was to review the radiolo...

Farmers lung disease is a common form of hypersensitivity pneumonitis (HP) and is characterized by inflammation and granuloma formation in the lung. Interferong is important for the expression of granulomatous diseases caused by infectious agents; however, the role this mediator in regulating expression of the granulomatous response to inhaled antigen is not known. To evaluate this, we compared...

Granulomatous inflammation is a distinctive form of chronic inflammation in which predominant cells include macrophages, epithelioid cells, and multinucleated giant cells. Mechanisms regulating granulomatous inflammation remain ill-understood. CD154, the ligand of CD40, is a key mediator of inflammation. CD154 confers a proinflammatory phenotype to macrophages and controls several macrophagic f...

BACKGROUND Immune checkpoint therapy has dramatically changed the landscape of cancer therapy, providing an efficacious and durable therapeutic option for patients with advanced-stage disease. However, dermatologic toxicities are a well-recognized side effect in patients receiving this therapy. A spectrum of immune related adverse events (irAEs) involving the skin can occur and include immunobu...

Paracoccidioidomycosis (PCM) is a fungal disease caused by Paracoccidioides spp., which can cause a systemic granulomatous infection with tegumentary and visceral involvement. Sarcoid-like skin lesions are uncommon and can be misdiagnosed due to similarities with other granulomatous diseases. We report a case of a women presenting with erythematous infiltrated plaques on her face that was treat...

Orofacial granulomatosis is a rare chronic inflammatory disorder characterized by persistent or recurrent soft tissue swellings, oral ulceration, and other orofacial features in the absence of an identifiable granulomatous disease. We report a case of a 61-year-old woman with recurrent ulcerations and swellings in her oral mucosa. She was diagnosed as orofacial granulomatosis based upon clinico...

Hypersensitivity pneumonitis (HP) is a granulomatous, inflammatory lung disease caused by inhalation of organic Ags, most commonly thermophilic actinomycetes that cause farmer's lung disease. The early response to Ag is an increase in neutrophils in the lung, whereas the late response is a typical Th1-type granulomatous disease. Many patients who develop disease report a recent viral respirator...

Following resections for ulcerative colitis and granulomatous enteritis there is a significant rise in serum IgM levels. The rise seen in IgM following resection does not occur after bypass surgery. No consistent changes were noted in the concentrations of IgA or IgG. There was no observed difference noted between patients with ulcerative colitis and granulomatous enteritis in the IgM response ...

Granulomatous response was examined in selective IgE-deficient SJA/9 mice infected with Schistosoma japonicum. The average size of granulomas formed around newly deposited eggs in SJA/9 mice was significantly smaller than that in control C57BL/6 or SJL/J mice, although the numbers of adult worms recovered from each strain were comparable among them. Thus, IgE antibody specific to allergenic com...