Belying the spectacular success of solid organ transplantation and improvements in immunosuppressive therapy is the reality that long-term graft survival rates remain relatively unchanged, in large part due to chronic and insidious alloantibody-mediated graft injury. Half of heart transplant recipients develop chronic rejection within 10 years - a daunting statistic, particularly for young pati...

In the current era of immunosuppressive medications there is increased observed incidence of graft dysfunction in the absence of known histological criteria of rejection after heart transplantation. A noninvasive molecular expression diagnostic test was developed and validated to rule out histological acute cellular rejection. In this paper we present for the first time, longitudinal pattern of...

Renal transplantation is a most valuable treatment for patients with end-stage renal disease as it offers improved survival and quality-of-life benefits compared with dialysis (Evans, Manninen et al. 1985; Port, Wolfe et al. 1993). However, there has been no satisfactory increase in long-term graft survival despite significant advances in the field of renal transplantation (Meier-Kriesche, Scho...

results during 2014, we encountered five patients with suspicious amr or tma at our kidney transplant center. renal biopsy was performed for two of them, suggesting amr for one patient and tma for another patient. all patients were treated with plasmapheresis plus ivig. in this center, as a routine practice, the cumulative dose of 2 g/kg of ivig was divided to 300 - 400 mg/kg after each plasmap...

background: human cornea expresses functional fas-ligand capable of killing fas+ activated lymphocytes. fas expression is partly regulated by -670 a/g polymorphism in the promoter region of fas gene. objective: the aim of the present study is to determine the association between fas-670a/g polymorphism and survival of corneal transplantation. methods: in 276 graft recipients who mainly underwen...

OBJECTIVES This study evaluates the concept and diagnostic efficacy of using serum troponin T for the detection of cardiac graft rejection. BACKGROUND Cardiac troponin T is a cardiospecific myofibrillar protein, which is only detectable in the circulation after cardiac myocyte damage. It might be expected to be released during acute heart allograft rejection, allowing noninvasive rejection di...

PURPOSE To report endothelial corneal graft rejection after administration of topical latanoprost eye drops. CASE REPORT Two eyes of two patients with a history of multiple intraocular procedures prior to penetrating keratoplasty developed endothelial graft rejection one month after administration of topical latanoprost. Cystoid macular edema developed simultaneously in one patient. CONCLUS...

BACKGROUND & OBJECTIVES In spite of potent immunosuppression, acute rejection continues to be the single largest cause of graft dysfunction after renal transplantation. Renal allograft biopsy, though invasive, continues to be the reference standard, though certain clinical and biochemical parameters are helpful in assessment of these patients. Acute renal allograft rejection is mediated by T ly...

Copyright © 2010 Massachusetts Medical Society. The science of kidney transplantation has progressed considerably in the past half-century largely because of an improved understanding of the role of the immune system in allograft rejection, the disentanglement of the molecular mechanisms underlying graft failure, and better management of immunosuppression.1,2 Rejection has always been the major...

Although corneal transplantation is performed on patients with densely vascularized corneas, the likelihood of immunologic rejection is greater than in the nonvascularized cornea. In other organ transplantation systems, immune rejection has been correlated with the degree of antigenic disparity of the major histocompatibility antigens (HL-A) between the donor and the recipient. In this study, w...