how to cite this article: paul sp, ahmed s, painless loss of vision as the first presentation of undiagnosed neurofibromatosis 1 in a child. iran j child neurol. autumn 2015;9(4):58-60. abstract objective a 10 year old presented with painless loss of vision as the first manifestation of neurofibromatosis 1 (nf1). clinical assessment detected diagnostic features of nf1 and magnetic resonance ima...

Background& Objective: Micro-vascular proliferation is an important histological feature of brain glioma with more vascular proliferation is present in higher grades of glioma. CD 105 is expressed in new actively proliferating and immature endothelial cells in tumor environment  and appears to be capable to distinguish between malignant neo-vasculature and normal vesse...

Introduction: Glioma is the most common type of primary brain tumor that originates from glial tissues. These types of tumors have a high degree of malignancy and poor prognosis and low survival rates. The evaluation response to treatment is essential to decide whether present treatment is adequate or need for alternative therapy. The aim of this study was to evaluate the resp...

To compare the efficacy of ultra-high and conventional mono-b-value DWI for glioma grading, in 109 pathologically confirmed glioma patients, ultra-high apparent diffusion coefficient (ADCuh)was calculated using a tri-exponential mode, distributed diffusion coefficients (DDCs) and α values were calculated using a stretched-exponential model, and conventional ADC values were calculated using a mo...

Fully integrated positron emission tomography (PET)/magnetic resonance imaging (MRI) scanners have been available for a few years. Since then, the number of scanner installations and published studies have been growing. While feasibility of integrated PET/MRI has been demonstrated for many clinical and preclinical imaging applications, now those applications where PET/MRI provides a clear benef...

OBJECTIVE In most studies, treatment decisions of brainstem glioma are based solely on MRI features and do not incorporate a histopathological diagnosis. In the current study, we sought to compare MRI characteristics with histopathological findings of bainstem glioma. METHODS From April 2003 through April 2012, 150 patients were diagnosed with brainstem gliomas by MRI and microsurgically trea...

BACKGROUND AND PURPOSE A grading system for experimental subarachnoid hemorrhage (SAH) that does not require animal euthanasia is currently unavailable. We proposed a new grading system based on MRI and evaluated the feasibility of this method in a mouse model of SAH. METHODS SAH was induced by endovascular perforation in adult male C57BL/6 mice. Mice underwent MRI 24 hours after SAH and were...

OBJECTIVES To assess patients with recurrent high grade brain glioma with the aim of evaluating facets of quality of life (QOL) and their association with mood, cognition, and physical performance. METHODS Ninety four glioma patients (four groups with different duration of glioma recurrence) were compared with 24 patients with other chronic neurological diseases and 48 healthy subjects. The F...

Introduction: Glioblastoma multiform is the most common malignant brain tumor, with an invasive nature. Despite the development of conventional therapies such as surgery, radiotherapy and chemotherapy, because of high recurrence rates, the prognosis remains very poor. Over the last decade, nanotechnology has represented an innovative method as nanoparticle-based drug delivery ...