Cellular retinol-binding proteins (CRBPs) I and II, which are members of the intracellular lipid-binding protein (iLBP) family, are retinoid chaperones that are responsible for the intracellular transport and delivery of both retinol and retinal. Although structures of retinol-bound CRBPI and CRBPII are known, no structure of a retinal-bound CRBP has been reported. In addition, the retinol-boun...

Angiosperms are renown for their diversity of flower colors. Often considered adaptations to pollinators, the most common underlying pigments, anthocyanins, are also involved in plants' stress response. Although the anthocyanin biosynthetic pathway is well characterized across many angiosperms and is composed of a few candidate genes, the consequences of blocking this pathway and producing whit...

Each Gr-category (or categorical group) is Gr-equivalent to a Grcategory of type (Π, A, ξ), where Π is a group, A is a Π-module and ξ is a 3-cocycle of Π, with coefficients in A. In this paper, first we show that each Gr-functor induces one between Gr-categories of type (Π, C). Then we give results on the existence of Gr-functor and the classification of Gr-functors by cohomology groups H(Π, C)...

Abstract Reactive synthesis is an automated procedure to obtain a correct-by-construction reactive system from its temporal logic specification. GR(1) expressive assume-guarantee fragment of LTL that enables efficient and has been recently used in different contexts application domains. A common form providing system's requirements through use cases, which are existential nature. However, GR(1)...

We have screened a panel of tetracycline (tc)-like compounds for their potential use with tc-repressor (tetR) based gene switches. The interaction between tc and tetR appears quite specific, as only tc itself and its close homologues anhydro-tc and doxycycline strongly inhibited DNA binding. However, a single tc-like compound, GR33076X, increased DNA binding of the tetR-VP16 fusion protein, bot...