نتایج جستجو برای: gpx1

تعداد نتایج: 540  

2017
Didier Dequanter Ruveyda Dok Louet Koolen Vincent Vander Poorten Sandra Nuyts

INTRODUCTION To date, no reliable prognostic biological marker for all squamous cell carcinoma located in different subsites of the head and neck region has been identified and used in daily routine. In line with our previous studies, in which we showed a role of glutathione and associated enzymes as potential biological markers, we investigated the relationship between GPx1 and prognosis of he...

Journal: :The Journal of clinical investigation 2014
Ziad A Ali Vinicio de Jesus Perez Ke Yuan Mark Orcholski Stephen Pan Wei Qi Gaurav Chopra Christopher Adams Yoko Kojima Nicholas J Leeper Xiumei Qu Kathia Zaleta-Rivera Kimihiko Kato Yoshiji Yamada Mitsutoshi Oguri Allan Kuchinsky Stanley L Hazen J Wouter Jukema Santhi K Ganesh Elizabeth G Nabel Keith Channon Martin B Leon Alain Charest Thomas Quertermous Euan A Ashley

Angioplasty and stenting is the primary treatment for flow-limiting atherosclerosis; however, this strategy is limited by pathological vascular remodeling. Using a systems approach, we identified a role for the network hub gene glutathione peroxidase-1 (GPX1) in pathological remodeling following human blood vessel stenting. Constitutive deletion of Gpx1 in atherosclerotic mice recapitulated thi...

Journal: :International journal of oncology 2016
Zhiquan Huang Yeqing Liu Zixian Huang Haifeng Li Xiangfeng Gan Zhuojian Shen

1,25-Dihydroxyvitamin D3 (1,25D3) is the active form of vitamin D with antineoplastic effects. The glutathione peroxidase-1 (GPX1) gene is associated with tumour progression. The present study aimed to explore the role of GPX1 in 1,25D3-mediated progression of salivary adenoid cystic carcinoma (SACC). Downregulating GPX1 expression inhibited SACC cell proliferation, chemoresistance, motility, a...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2012
Cheng Huang Guangyu Ding Chengyu Gu Jian Zhou Ming Kuang Yuan Ji Yifeng He Tadashi Kondo Jia Fan

PURPOSE We aimed to characterize the role of selenium-binding protein 1 (SBP1) in hepatocellular carcinoma (HCC) invasiveness and underlying clinical significance. EXPERIMENTAL DESIGN SBP1 expression was measured in stepwise metastatic HCC cell lines by Western blotting. The role of SBP1 in HCC was investigated using siRNA. Immunofluorescence analyses were used to detect the interaction betwe...

2017
Shasha Hong Li Hong Bingshu Li Debin Wu Cheng Liu Jie Min Wenjun Guo Ming Hu Jianming Tang Yang Li

Gestation and delivery can increase intra-abdominal pressure, which are well-known risk factors for Pelvic Organ Prolapse (POP). But the pathogenesis mechanism of POP remains unclear. Our previous research showed that the expression of glutathione peroxidase type 1 (GPX1) decreased in pelvic floor ligaments from POP patients, implying that oxidative stress (OS) may be related to POP. The aim of...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016
Huijie Gao Chao Liu Ping Lin Luo Xu Xiao Li Yujie Chen Baohua Cheng Aiqin Li Shiguo Liu

BACKGROUND/AIMS Increasing evidence shows that oxidative stress plays an important part in the pathophysiological mechanisms of preeclampsia (PE). Polymorphic variants of oxidative stress-related candidate genes GST1 and GPX1 can affect the antioxidant activities of their encoded enzymes. Therefore, this study aimed to explore the associational analysis between GSTP1 and GPX1 single nucleotide ...

Journal: :The Journal of biological chemistry 2011
Marina V Kasaikina Alexei V Lobanov Mikalai Y Malinouski Byung Cheon Lee Javier Seravalli Dmitri E Fomenko Anton A Turanov Lydia Finney Stefan Vogt Thomas J Park Richard A Miller Dolph L Hatfield Vadim N Gladyshev

Naked mole rat (MR) Heterocephalus glaber is a rodent model of delayed aging because of its unusually long life span (>28 years). It is also not known to develop cancer. In the current work, tissue imaging by x-ray fluorescence microscopy and direct analyses of trace elements revealed low levels of selenium in the MR liver and kidney, whereas MR and mouse brains had similar selenium levels. Thi...

Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2014

Journal: :Hypertension 2008
M Julia Brosnan

Much evidence supports the role of increased levels of reactive oxygen species (ROS) in the pathogenesis of cardiovascular diseases, including hypertension. The increased activity and expression of the reduced nicotinamideadenine dinucleotide phosphate oxidase observed in hypertensive populations have implicated the superoxide anion as one of the main species responsible. This view has been sup...

Journal: :Acta biochimica Polonica 2018
Magdalena B Król Michał Galicki Peter Grešner Edyta Wieczorek Ewa Jabłońska Edyta Reszka Zbigniew Morawiec Wojciech Wąsowicz Jolanta Gromadzińska

BACKGROUND The aim of this study was to establish whether the gene expression of estrogen receptor alpha (encoded by ESR1) correlates with the expression of glutathione peroxidase 1 (encoded by GPX1) in the tumor and adjacent tumor-free breast tissue, and whether this correlation is affected by breast cancer. Such relationships may give further insights into breast cancer pathology with respect...

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