Metabolomic screening of fasting plasma from nondiabetic subjects identified α-hydroxybutyrate (α-HB) and linoleoyl-glycerophosphocholine (L-GPC) as joint markers of insulin resistance (IR) and glucose intolerance. To test the predictivity of α-HB and L-GPC for incident dysglycemia, α-HB and L-GPC measurements were obtained in two observational cohorts, comprising 1,261 nondiabetic participants...

BACKGROUND Recent studies have suggested that alpha glycerylphosphorylcholine (A-GPC) may be an effective ergogenic aid. The present study was designed to assess the efficacy of two doses of A-GPC in comparison to placebo and caffeine for increasing countermovement jump performance, isometric strength, and psychomotor function. METHODS Forty-eight healthy, college aged males volunteered for t...

Generalized polynomial chaos (gPC) methods have been successfully applied to various stochastic problems in many physical and engineering fields. However, realistic representation of stochastic inputs associated with various sources of uncertainty often leads to high dimensional representations that are computationally prohibitive for classic gPC methods. Additionally in the classic gPC methods...

this paper the GPC and NGPC model predictive control techniques are applied to a typical plant and compared in terms of computational efficiency. The system identification and predictive control computational performance are examined. The future control inputs using GPC can be found by the direct analysis and thus reducing the computational time when compared with NGPC scheme with variable weig...

BACKGROUND We hypothesized that L-alpha-glycerylphosphorylcholine (GPC), a deacylatedphosphatidylcholine derivative, can influence the mitochondrial respiratory activity and in this way, may exert tissue protective effects. METHODS Rat liver mitochondria were examined with high-resolution respirometry to analyze the effects of GPC on the electron transport chain in normoxic and anoxic conditi...

Lactoferrin, an iron complexing protein in normal tears, is an important component of the nonspecific host defense system of the external eye. We measured tear lactoferrin levels in patients with contact lens-induced giant papillary conjunctivitis (GPC) by an enzyme-linked immunosorbent assay (ELISA). Patients with active GPC (N = 26) had significantly reduced tear levels of lactoferrin (0.876 ...

In this paper, Generalized Predictive Control (GPC) based on a Fuzzy Logic model is illustrated. The control technique is then applied to a selected nonlinear application to show the performance of the Fuzzy-Based Generalized Predictive Control (FGPC). The results of the presented FGPC method are compared with standard GPC and Proportional-Integral-Derivative Control (PID). The results revealed...

Generalized Partial Computation (GPC) is a program transformation method utilizing partial information about input data and auxiliary functions as well as the logical structure of a source program. GPC uses both an inference engine such as a theorem prover and a classical partial evaluator to optimize programs. Therefore, GPC is more powerful than classical partial evaluators but harder to impl...

The substrate requirements and specificity of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine (alkyllyso-GPC):acetyl-CoA acetyltransferase were investigated. The following findings were observed. 1) When the ether bond of alkyllyso-GPC is substituted with an ester linkage, the resulting compound, palmitoyllyso-GPC, can serve as a substrate, albeit at a reduced rate (50%). In addition, palmitoyllyso-...