PURPOSE As a potential protein therapeutic for type 2 diabetes mellitus (T2DM), BAY 55-9837 is limited by poor stability and a very short half-life in vivo. The purpose of this study was to construct a novel nanostructured biomaterial by conjugating BAY 55-9837 to chitosan-decorated selenium nanoparticles (CS-SeNPs) to prolong the in vivo half-life of BAY 55-9837 by reducing its renal clearance...

Kristin F. Butcher is an associate professor of economics at Wellesley College and a former senior economist at the Federal Reserve Bank of Chicago. Kyung H. Park is a senior associate economist at the Federal Reserve Bank of Chicago. The authors thank Dan Sullivan, Anna Paulson, Bhashkar Mazumder, and seminar participants at the Federal Reserve Bank of Chicago for helpful comments. The views e...

The current study focused to evaluate one of the important trace metal concentrations in mixed zooplankton from the waters of Bay of Bengal and Andaman Sea. The average concentration of copper from northern Bay of Bengal, central Bay of Bengal, southern Bay of Bengal, and eastern Bay of Bengal on dry weight basis was reported as 65.36 g.g -1 , 58.54 g.g -1 , 48.86 g.g -1 , 43.50 g.g -1 resp...

With a good-resolution mountain profile, we simulated the underground muon flux at the Daya Bay site. We modified the standard Gaisser’s formula to describe the muon flux at the sea-level. At large zenith angle or small muon energies, which may be important in the Daya Bay case, the modified formula describe the experimental data much better than the standard one. MUSIC code was used to transpo...

The racemic prodrug BAY R3401 suppresses hepatic glycogenolysis. BAY W1807, the active metabolite of BAY R3401, inhibits muscle glycogen phosphorylase a and b. We investigated whether BAY R3401 reduces hepatic glycogenolysis by allosteric inhibition or by phosphatase-catalyzed inactivation of phosphorylase. In gel-filtered liver extracts, racemic BAY U6751 (containing active BAY W1807) was test...

introduction tsunami is a series of water waves caused by the displacement of a large amount of water which is generated by underwater earthquake, volcano, landslide or other disturbances below water. the makran subduction zone (msz) is one of the regions that have potential to generate tsunami which also has been occurred in 1985 and is capable of another one. in msz, the coasts of chabahar ba...

We present observations of galaxy environmental dependencies using data from the 2dF Galaxy Redshift Survey. From a combined analysis of the luminosity function, Butcher-Oemler effect and trends in Hα line strengths we find support for a model where galaxy properties are mainly set by initial conditions at the time of their formation.

Soluble guanylate cyclase (sGC) has been suggested as a therapeutic target for cardiac ischemia-reperfusion (IR) injury. Until now, the molecular mechanism of BAY 60-2770, a sGC activator, in cardiac IR injury has not been assessed. To identify the cardioprotective effects of BAY 60-2770 in IR-injured rat hearts, IR injury was established by occlusion of LAD for 40 min and reperfusion for 7 day...

Systematic aerial line-transect surveys of beluga whales, Delphinapterus leucas, were conducted in James Bay, eastern Hudson Bay, and Ungava Bay from 14 August to 3 September 2001. An estimated 7901 (SE = 1744) and 1155 (SE = 507) belugas were present at the surface in the offshore areas of James Bay and Hudson Bay, respectively. An additional 39 animals were observed in estuaries during the co...

A nonlinear, 41⁄2-layer reduced-gravity ocean model with active thermodynamics and mixed layer physics is used to investigate the causes of sea level interannual variability in the Bay of Bengal, which may contribute to flooding and cholera outbreaks in Bangladesh. Forcing by NCEP–NCAR reanalysis fields from 1958 to 1998 yields realistic solutions in the Indian Ocean basin north of 298S. Contro...