نتایج جستجو برای: gossypol

تعداد نتایج: 670  

Journal: :Molecular cancer therapeutics 2011
Xiufeng Pang Yuanyuan Wu Yougen Wu Binbin Lu Jing Chen Jieqiong Wang Zhengfang Yi Weijing Qu Mingyao Liu

(-)-Gossypol, a natural BH3-mimetic and small-molecule Bcl-2 inhibitor, shows promise in ongoing phase II clinical trials for human cancers. However, whether (-)-gossypol plays functional roles in tumor angiogenesis has not been directly elucidated yet. In this study, we showed that (-)-gossypol dose dependently inhibited the expression of VEGF, Bcl-2, and Bcl-xL in human prostate cancer cells ...

2008
Jodi A. Scheffler Gabriela B. Romano

cotton (Gossypium hirsutum L.) and related species all contain gossypol, a polyphenolic compound that is an integral part of the cotton plant’s self-defense system against insect pests and possibly some diseases. gossypol also has been reported to have antitumor activity, medicinal effects, and contraceptive properties. However, the compound can be toxic to animals, which limits the usefulness ...

2017
Simon Zebelo Joseph Disi Rammohan Balusu Benjamin Reeves Henry Fadamiro

Cotton plants induce high levels of gossypol in response to herbivore damage. However, little is known about the mechanisms by which insect herbivory modulates gossypol biosynthesis in cotton plants. Here, we report the mechanism by which herbivore damage or insect-originated elicitors modulate the biosynthesis of gossypol and jasmonic acid (JA) in plants. Spodoptera exigua larval-damaged (HD) ...

Journal: :FEMS microbiology letters 2005
Barbara Weissenmayer Katrina Boeckeler Angela Lahrz Rupert Mutzel

The Dictyostelium genome harbors single copy genes for both the catalytic and regulatory subunits of the Ca2+/calmodulin-dependent protein phosphatase calcineurin. Since molecular genetic approaches to reduce the expression of these genes have failed so far, we attempted to pharmacologically target calcineurin activity in vivo by using the recently described calcineurin inhibitor, gossypol. Up-...

One of our objectives in this investigation is to determine responses of S. littoralis through different developmental stages and generations to secondary metabolic compound presumably gossypol. Gossypol did not significantly show antifeedant except with high concentration (1.7% gossypol in the diet) that gave 10.6, 21.9, and 46.8% for three generations, respectively. Significantly longer larva...

One of our objectives in this investigation is to determine responses of S. littoralis through different developmental stages and generations to secondary metabolic compound presumably gossypol. Gossypol did not significantly show antifeedant except with high concentration (1.7% gossypol in the diet) that gave 10.6, 21.9, and 46.8% for three generations, respectively. Significantly longer larva...

2015
Antônio Carlos Lopes Câmara Ivana Cristina Nunes Gadelha Pedro Augusto Cordeiro Borges Silvano Alves de Paiva Marília Martins Melo Benito Soto-Blanco Salah A Sheweita

Gossypol, a polyphenol compound produced by cotton plant, has proven reproductive toxicity, but the effects of gossypol on sheep ovaries are unknown. This study was aimed to determine the in vitro and in vivo effects of gossypol on the ovarian follicles of sheep. This trial was divided into two experiments. In the first one, we used twelve non-pregnant, nulliparous, Santa Inês crossbred ewes, w...

Journal: :Molecular cancer therapeutics 2005
Liang Xu Dajun Yang Shaomeng Wang Wenhua Tang Meilan Liu Mary Davis Jianyong Chen James M Rae Theodore Lawrence Marc E Lippman

Radioresistance markedly impairs the efficacy of tumor radiotherapy and involves antiapoptotic signal transduction pathways that prevent radiation-induced cell death. The majority of human prostate cancers overexpress the important antiapoptotic proteins Bcl-2 and/or Bcl-xL, which render tumors resistant to radiation therapy. (-)-Gossypol, a natural polyphenol product from cottonseed, has recen...

Journal: :Animal : an international journal of animal bioscience 2008
T A Taha W F Shaaban F D El-Nouty M H Salem

This study was done to evaluate the effects of two sublethal doses of gossypol (4 and 20 mg/kg of BW, every other day) on some amino and fatty acid concentrations in male rabbit seminal plasma. Rabbits were chosen as an experimental animal owing to the fact that they are excellent model for reproductive toxicological effects. The experiment lasted 16 weeks and included two periods: a treatment ...

Journal: :Physiological research 2001
J Kolena S Vrsanská E Nagyová M Jezová

The role of gossypol in the cumulus expansion of oocyte-cumulus complexes (OCC) isolated from large antral porcine follicles was investigated. Marked suppression of cumulus expansion stimulated with follicle-stimulating hormone (FSH) and epidermal growth factor (EGF) was observed in the presence of different concentrations of gossypol. Comparable inhibitory effects were obtained in the presence...

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