Since the general use of iodine prophylactically in endemic goitre areas gross enlargement of the thyroid gland at birth has become relatively uncommon. Wegelin's (1926) series in the preiodine period of 223 consecutive necropsies on newborn infants in a goitre area between 1911 and 1921 showed that 340% had thyroid glands weighing over 6 g. The normal weight of the gland at birth in a healthy ...

OBJECTIVE To assess the iodine status of Sherpa residents living in Kunde village, Khumbu region, Nepal. DESIGN Prevalence of goitre was determined by palpation. Urinary iodine concentrations (UIC) were determined in casual morning samples, and thyroid-stimulating hormone (TSH) in finger-prick blood samples on filter paper. Dietary and demographic data were obtained via questionnaire, and sel...

In this article Pendred's syndrome, which is the combination of - congenital goitre with deafmutism, is discussed. This type of goitre is due to a special enzymatic defect, involving  a process of hormonogenesis, which is respon-· sible for the incorporation of iodide in the tyrosine molecule.  A case of pendred's syndrome is presented  in a 16-year-old girl. This girl has never been able to...

Aim: The aim of the study is examining factors determining need for thoracic approaches to remove an intrathoracic goitre. 
 Material and Method: This retrospective was conducted between 2011 2018. Patients were categorized into two groups; Group A consisted patients who underwent surgery via transcervical approach, B plus approaches. extension, size, localization goitre measured on comput...

The region of Grobnik, in the north west of Croatia, 15 km away from the Adriatic coast and 400 meters above the sea level, used to be known as a centre of endemic goitre. Iodine prophylaxis of 10 mg KJ added per kilo salt started in Croatia during the year 1953 and it was increased to 25 mg KJ per kilo in 1996. During 1961, the prevalence of goitre among Grobnik school children was 63%, while ...

THE MODERN surgeon approaches the surgery of thyrotoxicosis with confidence, the confidence derived from the excellence of modem anaesthesia, the euthyroid state of the patient and the knowledge that blood transfusion, antibiotics and the specific management of the occasional crisis are always available to extricate the patient from any of these complications. Though full of confidence in his o...

Retrosternal goitre is defined as a goitre with a portion of its mass > or = 50% located in the mediastinum. Surgical removal is the treatment of choice and, in most cases, the goitre can be removed via a cervical approach. Aim of this retrospective study was to analyse personal experience in the surgical management of retrosternal goitres, defining, in particular, the features requiring sterno...

Endemic goitre has been reported in the climatic wet zone of south-west Sri Lanka for the past 50 years, but rarely occurs in the northern dry zone. Despite government-sponsored iodised salt programmes, endemic goitre is still prevalent. In recent years, it has been suggested that Se deficiency may be an important factor in the onset of goitre and other iodine deficiency disorders (IDD). Prior ...

Despite a successful national salt iodinization programme, endemic goitre still persists in Iranian children. In a cross-sectional study in Arak the prevalence of goitre was 5.2% in a sample of 6520 primary-school children. Subsamples of 193 children with goitre and 151 healthy children were assessed for urinary iodine excretion, thyroid hormone profile, insulin-like growth factor-1 (ICF-1) and...

Ninety-seven fixed surgical thyroid specimens and 63 unfixed and 40 fixed thyroid specimens from autopsies were examined for their oxalate content. Proteases were used to process the tissue, and the oxalate was determined with an enzymatic assay. The fixed samples were grouped into seven diagnostic categories (diffuse colloid goitre; partially diffuse, partially nodular colloid goitre; nodular ...