OBJECTIVE The objective of this study is to evaluate if gonadotropin-releasing hormone agonist (GnRHa) trigger is a better alternative to human chorionic gonadotropin (hCG) in polycystic ovary syndrome (PCOS) of Indian origin undergoing in vitro fertilization (IVF) cycles with GnRH antagonist for the prevention of ovarian hyperstimulation syndrome (OHSS). DESIGN Prospective randomized control...

Although gonadotropin-releasing hormone agonists (GnRHa) have been used in the therapy of the endocrine-dependent cancers, their biological mechanism remained obscure. We have studied the roles of mitogen-activated protein kinase family in the antiproliferative effect of GnRHa on the Caov-3 human ovarian cancer cell line. Reverse transcription-PCR assays confirmed mRNA for GnRH receptor in Caov...

The aim of this study was to investigate the effects of different Luteinizing hormone (LH) and steroid hormones levels on LH receptor (LHR) expression in the hippocampal cells. Rats (24 males and 24 females) were assigned to four groups: one control and three experimental [gonadectomy (GDX), gonadectomy + gonadotropin releasing hormone analogue (GDX+GnRHa) and GDX+GnRHa+estradiol (E2) or testos...

Gonadotropin-releasing hormone analogs (GnRHa) are widely used to treat central precocious puberty (CPP). The efficacy and safety of GnRHa treatment are known, but concerns regarding long-term complications are increasing. Follow-up observation results after GnRHa treatment cessation in female CPP patients up to adulthood showed that treatment (especially <6 years) was beneficial for final adul...

PURPOSE There is controversy surrounding the growth outcomes of treatment with gonadotropin-releasing hormone agonist (GnRHa) in central precocious puberty (CPP). We analyzed height preservation after treatment with GnRHa with and without growth hormone (GH) in girls with CPP. METHODS We reviewed the medical records of 82 girls with idiopathic CPP who had been treated with GnRHa at Severance ...

PURPOSE Treatment with cyclophosphamide (CYC) confers up to a 40% risk of ovarian failure in women of reproductive age. The use of GnRH agonists (GnRHa) to preserve ovarian function has been investigated in several small studies. We performed a systematic review of studies examining whether a GnRHa administered during chemotherapy is protective of ovarian function and fertility. METHODS We se...

During the in vitro fertilization treatment, human chorionic gonadotrophin (hCG) is routinely used as a substitute for natural endogenous LH surge during final stage of oocyte maturation. However, it does not provide FSH observed mid-cycle cycle. To date, whether can improve quality and pregnancy outcomes remains unknown. Randomized controlled trials comparing following four trigger methods to ...

Abstract Study question Is there an advantage for modified flare/ GnRH antagonist protocol in comparison to oocyte cryopreservation cycles? Summary answer Modified is at least as good cycles, potentially improving maturity rate subgroup of patients. What known already Ultrashort flare agonist (GnRHa)/GnRH -antagonist offer benefits stimulatory effect repeated microdose on endogenous FSH and the...

It is now known that gonadotrophin-releasing hormone analogues (GnRHa) are extremely efficient at reducing uterine fibroid volume and reversing the related symptomatology. However, the fibroids tend to return to their pretreatment size about 6 months after discontinuing treatment. GnRHa treatment cannot be continued indefinitely due to its potential complications and high cost. It is therefore ...

The efficacy of GnRH agonists (GnRHa) as a method for protecting fertility has been controversially discussed for years. This is clearly demonstrated by the fact that there are now more meta-analyses on this subject than individual studies. However, the discussion is often not conducted objectively but seems to be shaped by fundamental ideologies, leading to a scientific dispute between GnRHa a...