نتایج جستجو برای: gnb3 gene

تعداد نتایج: 1141400  

Journal: :Pharmacological reports : PR 2012
Anna Banaś Edyta Płońska Barbara Larysz Mateusz Kurzawski Marek Droździk

There is a wide interpersonal difference to dobutamine response during dobutamine stress echocardiography (DSE). The aim of this study was to determine an association between GNB3 825C>T gene polymorphism, encoding the β3-subunit of G protein, and heart rate (HR), systolic (SBP) and diastolic blood pressure (DBP) response to dobutamine during DSE. The study involved 119 patients with clinical i...

2012
Han Gyeol Kim Kwang Jae Lee Sun Gyo Lim Jae Yeon Jung Sung Won Cho

BACKGROUND/AIMS Guanine nucleotide binding protein (G-protein) beta polypeptide 3 (GNB3) C825T polymorphism alters intracellular signal transduction, which may lead to motor or sensory abnormalities of the gastrointestinal tract. The aim of the present study was to evaluate the association of the GNB3 C825T polymorphism with susceptibility to overlap syndrome of functional dyspepsia (FD) and ir...

Journal: :Biological research 2013
Huan Zheng Huifeng Xu Bin Cui Nanzi Xie Zhi Wang Ming Luo

PURPOSE The G-protein β3-subunit gene C825T polymorphism (GNB3-C825T) has been reported to be associated with essential hypertension (EH), but results from previous studies are conflicting. The present study aimed at investigating the association between this polymorphism and risk of EH using a meta-analysis on the published studies. MATERIALS AND METHODS PubMed, Embase, CBM (China Biological...

Journal: :Hypertension 2001
R Zeltner C Delles M Schneider W Siffert R E Schmieder

The C825T polymorphism of the gene encoding the G-protein beta(3) subunit (GNB3) is associated with increased intracellular signal transduction and arterial hypertension. The aim of the study was to investigate the impact of this polymorphism on early adaptive processes of the left ventricle and renal hemodynamic changes in young normotensive to mildly hypertensive subjects. Ninety-five white m...

2017
Yongjun He Lijun Liu Pengcheng Xu Na He Dongya Yuan Longli Kang Tianbo Jin

High altitude pulmonary edema (HAPE) occurs mainly under conditions such as high altitude, rapid ascent, or hypoxia. Previous studies suggest that ADRB2, GNB3, TH, and GSTP1 polymorphisms are associated with various lung diseases. We evaluated whether those polymorphisms are associated with the risk of HAPE in a Chinese Han population. ADRB2, GNB3, TH and GSTP1 polymorphisms were genotyped usin...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2010
Tomoyuki Shibata Tomomitsu Tahara Joh Yonemura Masaaki Okubo Daisuke Yoshioka Masakatsu Nakamura Takamitsu Ishizuka Tomiyasu Arisawa Ichiro Hirata

From epidemiological evidence a high salt diet is a risk factor for gastric cancer, independent of Helicobacter pylori infection, and animal studies have shown that salt promotes carcinogenesis. The G-protein β 3(GNB3) C825T polymorphism has been linked with hypertension, salt sensitivity and multiple diseases. Our aim in this study was to clarify any association of the GNB3 C825T polymorphism ...

2016
Yi-Zuo Song He-Yi You Zhe-Hui Zhu Zheng-De Wen Hui-Ying Xu Bi-Cheng Chen Zong-Jing Chen Qing-Ke Huang

Background. Functional dyspepsia (FD) is a functional upper gastrointestinal disorder with significant morbidity and medical costs. Previous studies investigated the association of G-protein β3 (GNB3) genetic polymorphisms with FD but with inconsistent results. Therefore, we performed a meta-analysis to derive a precise estimation of the relationship between GNB3 polymorphisms and FD. Methods. ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Sergei S Nikonov Arkady Lyubarsky Marie E Fina Elena S Nikonova Abhishek Sengupta Chidambaram Chinniah Xi-Qin Ding Robert G Smith Edward N Pugh Noga Vardi Anuradha Dhingra

Mammalian cones respond to light by closing a cGMP-gated channel via a cascade that includes a heterotrimeric G-protein, cone transducin, comprising Gαt2, Gβ3 and Gγt2 subunits. The function of Gβγ in this cascade has not been examined. Here, we investigate the role of Gβ3 by assessing cone structure and function in Gβ3-null mouse (Gnb3(-/-)). We found that Gβ3 is required for the normal expres...

2015
David Lagman Amalia Callado-Pérez Ilkin E. Franzén Dan Larhammar Xesús M. Abalo

Gene duplications provide raw materials that can be selected for functional adaptations by evolutionary mechanisms. We describe here the results of 350 million years of evolution of three functionally related gene families: the alpha, beta and gamma subunits of transducins, the G protein involved in vision. Early vertebrate tetraploidisations resulted in separate transducin heterotrimers: gnat1...

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