The synthesis by transmetallation and in-depth characterisation IR spectroscopy of five half-sandwich ruthenium osmium dithiocarbamato isonipecotamide glycoconjugate complexes are presented herein. evaluation their in vitro cytotoxicity the zinc precursors’ towards ovarian cancer (A2780 A2780cisR) normal prostate (PNT2) cells is reported. While compounds rather limited, some selectivity observed.

PURPOSE To determine the subtypes of cholinergic muscarinic receptors and receptors for vasoactive intestinal peptide (VIP) present in rat conjunctival goblet cells and whether cholinergic agonists and VIP stimulate goblet cell secretion. METHODS Immunofluorescence studies were performed using antibodies against the m1, m2, and m3 muscarinic receptor subtypes and VIP receptors 1 and 2 (VIPR1 ...

BACKGROUND Glycoconjugated vaccines composed of polysaccharide antigens covalently linked to immunogenic carrier proteins have proved to belong to the most effective and safest vaccines for combating bacterial pathogens. The functional transfer of the N-glycosylation machinery from Campylobacter jejuni to the standard prokaryotic host Escherichia coli established a novel bioconjugation methodol...

Absnuct: Generally convergent strategies are employed in glyconjugate synthesis, hence the oligosaccharide moiety and the aglycon moiety are separately prepared and then linked to yield the target molecule; for glycopeptides linear synthesis strategies are more successful. The importance of p-glycosidic linkages of glucosamine and galactosamine in glycoconjugates was reason for the development ...

BACKGROUND It has been previously demonstrated that patients with reflux esophagitis exhibit a significant impairment in the secretion of salivary protective components versus controls. However, the secretion of salivary protective factors in patients with nonerosive reflux disease (NERD) is not explored. The authors therefore studied the secretion of salivary volume, pH, bicarbonate, nonbicarb...

Three important physical properties which may affect the performance of glycoconjugate vaccines against serious disease are molar mass (molecular weight), heterogeneity (polydispersity), and conformational flexibility in solution. The dilute solution behaviour of native and activated capsular polyribosylribitol (PRP) polysaccharides extracted from Haemophilus influenzae type b (Hib), and the co...